Redox-Responsive Disulfide Cross-Linked PLA-PEG Nanoparticles
Open accessAbstract
Abstract We have developed a strategy for the preparation of redox-responsive PEG–PLA-based nanoparticles containing disulfide bonds that can be disassembled in the presence of cellular concentrations of glutathione. Functionalized poly(lactide)s were prepared by ring-opening copolymerization of l-lactide and 3-methyl-6-(tritylthiomethyl)-1,4-dioxane-2,5-dione, a monomer bearing a pendant trityl-thiol group, followed by the postpolymerization modification of trityl-thiol into pyridyl disulfide groups. Polymeric networks composed of PLA and PEG blocks linked by disulfide bonds were prepared by a disulfide exchange reaction between the functionalized PLAs and telechelic PEG having thiol groups at both ends, HS-PEG-SH, in DMF. When dialyzed against water, they assembled into dispersible nanoparticles, with a flowerlike structure having a hydrophobic core and a hydrophilic shell, with sizes in the range 167–300 nm that are suitable for drug delivery. The effects of the number of functional groups, molecular weight, and concentration on the nanoparticle size were evaluated. The stability of the nanoparticles after dilution and the redox-responsive behavior in the presence of different concentrations of glutathione were assessed. The hydrophobic molecule Nile red could be encapsulated in the nanoparticles and then released in the presence of glutathione at cellular concentration.
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This family of catalysts was highly versatile and active in ROP of traditional cyclic esters (glycolide, lactide, caprolactone), large ring macrolactone, and novel thiol-functionalized lactide.
“This family of catalysts were highly versatile and active not only in the ROP of traditional cyclic esters i.e., glycolide, lactide and caprolactone [30,31], but also oflarge ring macrolactone [32,33] and ofnovel synthetized thiol-functionalized lactide [34,35].”
From Thermo-Rheological and Shape Memory Properties of Block and Random Copolymers of Lactide and ε-Caprolactone (2021) · cites this paper as [35]
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Cites
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533 · see citing works
Cheng, R., Feng, F., Meng, F., Deng, C., Feijén, J., & Zhong, Z. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.01.030 · Cited by 1,367 · see citing works
Letchford, K., & Burt, H. M. (2006) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2006.11.009 · Cited by 1,145 · see citing works
Reduction-sensitive polymers and bioconjugates for biomedical applications
Meng, F., Hennink, W. E., & Zhong, Z. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.026 · Cited by 1,132 · see citing works
Owen, S. C., Chan, D. P. Y., & Shoichet, M. S. (2012) · Nano Today · doi:10.1016/j.nantod.2012.01.002 · Cited by 911 · see citing works
Stimuli-Responsive Supramolecular Assemblies of Linear-Dendritic Copolymers
Gillies, E. R., Jonsson, T. B., & Fréchet, J. M. J. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0463738 · Cited by 549 · see citing works
Functional aliphatic polyesters for biomedical and pharmaceutical applications
Seyednejad, H., Ghassemi, A. H., van Nostrum, C. F., Vermonden, T., & Hennink, W. E. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.12.016 · Cited by 425 · see citing works
Zhou, S., Deng, X., & Yang, H. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00207-2 · Cited by 384 · see citing works
Polymeric nanostructured materials for biomedical applications
Tang, Z., He, C., Tian, H., Ding, J., Hsiao, B. S., Chu, B., & Chen, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.05.005 · Cited by 364 · see citing works
Glutathione responsive polymers and their application in drug delivery systems
Quinn, J. F., Whittaker, M. R., & Davis, T. P. (2016) · Polymer Chemistry · doi:10.1039/c6py01365a · Cited by 281 · see citing works
Surface-Functionalizable Polymer Nanogels with Facile Hydrophobic Guest Encapsulation Capabilities
Ryu, J., Jiwpanich, S., Chacko, R. T., Bickerton, S., & Thayumanavan, S. (2010) · Journal of the American Chemical Society · doi:10.1021/ja102316a · Cited by 211 · see citing works
Simultaneous and Reversible Functionalization of Copolymers for Biological Applications
Ghosh, S., Basu, S., & Thayumanavan, S. (2006) · Macromolecules · doi:10.1021/ma061420x · Cited by 177 · see citing works
Pounder, R. J., & Dove, A. P. (2010) · Polymer Chemistry · doi:10.1039/b9py00327d · Cited by 170 · see citing works
Polymer-based drug delivery systems for cancer treatment
Guo, X., Wang, L., Xiao, W., & Zhou, S. (2016) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.28252 · Cited by 137 · see citing works
Thiol‐X Chemistries in Polymer and Materials Science
Royal Society of Chemistry (2013) · Royal Society of Chemistry eBooks · doi:10.1039/9781849736961 · Cited by 129 · see citing works
Achieving Micelle Control through Core Crystallinity
Glavas, L., Olsén, P., Odelius, K., & Albertsson, A. (2013) · Biomacromolecules · doi:10.1021/bm401312j · Cited by 123 · see citing works
Jackson, A. W., & Fulton, D. A. (2012) · Macromolecules · doi:10.1021/ma202721s · Cited by 121 · see citing works
Lee, W., Li, Y., & Chu, I. (2006) · Macromolecular Bioscience · doi:10.1002/mabi.200600101 · Cited by 111 · see citing works
Garofalo, C., Capuano, G., Sottile, R., Tallerico, R., Adami, R., Reverchon, E., Carbone, E., Izzo, L., & Pappalardo, D. (2013) · Biomacromolecules · doi:10.1021/bm401812r · Cited by 92 · see citing works
Design of Controlled Drug Delivery System Based on Disulfide Cleavage Trigger
Yang, D. S., Chen, W., & Hu, J. (2014) · The Journal of Physical Chemistry B · doi:10.1021/jp507763a · Cited by 89 · see citing works
Approach to Formation of Multifunctional Polyester Particles in Controlled Nanoscopic Dimensions
van der Ende, A. E., Kravitz, E. J., & Harth, E. M. (2008) · Journal of the American Chemical Society · doi:10.1021/ja711417h · Cited by 88 · see citing works
A Facile Method for the Synthesis of Cleavable Block Copolymers from ATRP-Based Homopolymers
Klaikherd, A., Ghosh, S., & Thayumanavan, S. (2007) · Macromolecules · doi:10.1021/ma071852n · Cited by 86 · see citing works
Synthesis and biomedical applications of functional poly(α-hydroxyl acid)s
Yu, Y., Zou, J., & Cheng, C. (2014) · Polymer Chemistry · doi:10.1039/c4py00667d · Cited by 82 · see citing works
Cyclohexyl-Substituted Polyglycolides with High Glass Transition Temperatures
Jing, F., Smith, M. R., & Baker, G. L. (2007) · Macromolecules · doi:10.1021/ma071430d · Cited by 67 · see citing works
Fuoco, T., Finne-Wistrand, A., & Pappalardo, D. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.6b00005 · Cited by 46 · see citing works
Ren, J., Hong, H., Song, J., & Ren, T. (2005) · Journal of Applied Polymer Science · doi:10.1002/app.22070 · Cited by 30 · see citing works
Lin, L., Juang, L., Wang, C., Chen, Y., Lin, C., & Chang, K. (2010) · Journal of Experimental & Clinical Medicine · doi:10.1016/s1878-3317(10)60002-2 · Cited by 17 · see citing works
Strategies in Aliphatic Polyester Synthesis for Biomaterial and Drug Delivery Applications
Silvers, A. L., Chang, C., Parrish, B., & Emrick, T. S. (2012) · ACS symposium series · doi:10.1021/bk-2012-1114.ch015 · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Khemani, K., Scholz, C., Eds.; American Chemical Society: 2012; Vol. 1114, pp 237-254.
- Lowe, A. B., Bowman, C. N., Eds.; Royal Society of Chemistry: Cambridge, 2013.
Cited by
Sorted by citations
Strianese, M., Pappalardo, D., Mazzeo, M., Lamberti, M., & Pellecchia, C. (2020) · Dalton Transactions · doi:10.1039/d0dt02639e · Cited by 68 · see citing works
Stimuli-responsive nanoliposomes as prospective nanocarriers for targeted drug delivery
Bilal, M., Qindeel, M., Raza, A., Mehmood, S., & Rahdar, A. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102916 · Cited by 63 · see citing works
The effect of filler localization on the properties of biopolymer blends, recent advances: A review
Mochane, M. J., Sefadi, J. S., Motsoeneng, T. S., Mokoena, T. E., Mofokeng, T. G., & Mokhena, T. C. (2020) · Polymer Composites · doi:10.1002/pc.25590 · Cited by 58 · see citing works
Peng, H., Huang, X., Melle, A., Karperien, M., & Pich, A. (2019) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2019.01.049 · Cited by 55 · see citing works
Oh, J. K. (2019) · Polymer Chemistry · doi:10.1039/c8py01808a · Cited by 50 · see citing works
Reversible networks of degradable polyesters containing weak covalent bonds
Bednarek, M., & Kubisa, P. (2019) · Polymer Chemistry · doi:10.1039/c8py01731j · Cited by 45 · see citing works
Schäfer, O., & Barz, M. (2018) · Chemistry - A European Journal · doi:10.1002/chem.201800681 · Cited by 42 · see citing works
Cheng, G., Kwong, C. H. T., Sun, C., Li, Z., Lu, S., Yang, Y., Lee, S. M., & Wang, R. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c05013 · Cited by 34 · see citing works
Pyridyl Disulfide Functionalized Polymers as Nanotherapeutic Platforms
Sui, B., Cheng, C., & Xu, P. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201900062 · Cited by 33 · see citing works
Recent advances in biomedical applications of smart nanomaterials: a comprehensive review
Goshisht, M. K., Goshisht, A., Bajpai, A., & Bajpai, A. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00137d · Cited by 35 · see citing works
Targeted delivery, drug release strategies, and toxicity study of polymeric drug nanocarriers
Abasian, P., Shakibi, S., Maniati, M. S., Khorasani, S. N., & Khalili, S. (2020) · Polymers for Advanced Technologies · doi:10.1002/pat.5168 · Cited by 31 · see citing works
Meher, N., Seo, K., Wang, S., Bidkar, A. P., Fogarty, M., Dhrona, S., Huang, X., Tang, R., Blaha, C., Evans, M. J., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c16383 · Cited by 28 · see citing works
Naddeo, M., Sorrentino, A., & Pappalardo, D. (2021) · Polymers · doi:10.3390/polym13040627 · Cited by 25 · see citing works
“, glycolide, lactide and caprolactone [30,31], but also oflarge ring macrolactone [32,33] and ofnovel synthetized thiol-functionalized lactide [34,35].”
BackgroundFerrentino, N., Kohlan, T. B., Mehrtashfar, S., Finne‐Wistrand, A., & Pappalardo, D. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c00889 · Cited by 26 · see citing works
Alginate-Based Amphiphilic Block Copolymers as a Drug Codelivery Platform
Feng, Y., Quinnell, S. P., Lanzi, A. M., & Vegas, A. J. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c01525 · Cited by 26 · see citing works
Enhancing Photothermal Therapy Efficacy by In Situ Self-Assembly in Glioma
Song, W., Zhang, X., Song, Y., Fan, K. S., Shao, F., Long, Y., Gao, Y., Cai, W., & Lan, X. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c14413 · Cited by 23 · see citing works
Kalelkar, P. P., Geng, Z., Finn, M. G., & Collard, D. M. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b00504 · Cited by 22 · see citing works
Ferrentino, N., Romano, M. P., Zappavigna, S., Abate, M., Vecchio, V. D., Romano, D., Germinario, C., Grifa, C., Filosa, R., & Pappalardo, D. (2023) · Polymers · doi:10.3390/polym15051179 · Cited by 20 · see citing works
Kalelkar, P. P., & Collard, D. M. (2020) · Macromolecules · doi:10.1021/acs.macromol.9b02467 · Cited by 20 · see citing works
Kalelkar, P. P., Geng, Z., Cox, B., Finn, M. G., & Collard, D. M. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.112242 · Cited by 19 · see citing works
Calik, F., Degirmenci, A., Sanyal, R., & Sanyal, A. (2023) · European Polymer Journal · doi:10.1016/j.eurpolymj.2023.112548 · Cited by 18 · see citing works
Yassin, M. A., Fuoco, T., Mohamed‐Ahmed, S., Mustafa, K., & Finne‐Wistrand, A. (2019) · Macromolecular Bioscience · doi:10.1002/mabi.201900049 · Cited by 18 · see citing works
Gazzotti, S., Ortenzi, M., Farina, H., Disimino, M., & Silvani, A. (2020) · Macromolecules · doi:10.1021/acs.macromol.0c01537 · Cited by 12 · see citing works
Degirmenci, A., Sanyal, R., Klok, H., & Sanyal, A. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c05856 · Cited by 15 · see citing works
Antoniraj, M. G., Dhayanandamoorthy, Y., Ponnuchamy, K., Kandasamy, R., & Devi, K. P. (2024) · Carbohydrate Research · doi:10.1016/j.carres.2024.109049 · Cited by 14 · see citing works
Gholizadeh, M. R., Roghani‐Mamaqani, H., & Haddadi‐Asl, V. (2025) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2025.101174 · Cited by 13 · see citing works
Main Chain Modified Polylactides. Methods of Synthesis and Applications
Biela, T., Kubisa, P., & Łapienis, G. (2024) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/15583724.2024.2333742 · Cited by 12 · see citing works
Wettability regulation of membranes based on biodegradable aliphatic polyester
Deng, J., Yu, W., Zhan, L., Zhu, X., Fang, Y., Zhang, P., Ke, Q., & Huang, C. (2024) · Journal of Membrane Science · doi:10.1016/j.memsci.2024.123199 · Cited by 12 · see citing works
Fuoco, T., & Finne‐Wistrand, A. (2019) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/15583724.2019.1625059 · Cited by 12 · see citing works
Gheluwe, L. V., Buchy, E., Chourpa, I., & Munnier, E. (2020) · Polymers · doi:10.3390/polym12102350 · Cited by 11 · see citing works
Tafazoli, S., Shahrokhinia, A., Rijal, S., Garay, J., Scanga, R. A., & Reuther, J. F. (2023) · Polymer Chemistry · doi:10.1039/d3py00922j · Cited by 9 · see citing works
Nizamov, T. R., Iliasov, A., Vodopyanov, S., Kozhina, I. V., Bordyuzhin, I. G., Геннадьевич, Ж. Д., Ivanova, A. V., Permyakova, E. S., Mogil’nikov, P. S., Vishnevskiy, D. A., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010127 · Cited by 9 · see citing works
Zou, H., Wu, Q., Li, Q., Wang, C., Zhou, L., Hou, X., & Yuan, W. (2019) · Polymer Chemistry · doi:10.1039/c9py01566c · Cited by 8 · see citing works
Doustmihan, A., Akbari, M., Jaymand, M., Liu, G., & Jahanban‐Esfahlan, R. (2025) · Materials & Design · doi:10.1016/j.matdes.2025.115098 · Cited by 7 · see citing works
Sana, B., Ferrentino, N., Kohlan, T. B., Liu, Y., Pašiškevičius, V., Finne‐Wistrand, A., & Pappalardo, D. (2022) · European Polymer Journal · doi:10.1016/j.eurpolymj.2022.111760 · Cited by 7 · see citing works
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Masclef, J., Acs, E. M. N., Koehnke, J., Prunet, J. A., & Schmidt, B. V. K. J. (2024) · Macromolecules · doi:10.1021/acs.macromol.4c00528 · Cited by 6 · see citing works
Gazzotti, S., Ortenzi, M., Farina, H., & Silvani, A. (2020) · Polymers · doi:10.3390/polym12102396 · Cited by 4 · see citing works
Construction of poly(amino acid)s nano-delivery system and sustained release with redox-responsive
Hu, Z., Wang, G., Zhang, R., Wang, L., Wang, J., Hu, J., & Reheman, A. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113232 · Cited by 6 · see citing works
Kar, M., & Mandal, T. K. (2025) · Macromolecules · doi:10.1021/acs.macromol.4c02390 · Cited by 5 · see citing works
Highly isotactic polylactide by binary organocatalyzed polymerization of 1,3-dioxolan-4-ones
Wang, M., Lee, S., Lee, H., & Kim, B. (2025) · Polymer Chemistry · doi:10.1039/d5py00205b · Cited by 5 · see citing works
Kamalakannan, M., & Komala, G. (2025) · Journal of Environmental Management · doi:10.1016/j.jenvman.2025.126559 · Cited by 5 · see citing works
Gheluwe, L. V., David, S., Buchy, E., Chourpa, I., & Munnier, E. (2023) · Materials · doi:10.3390/ma16020539 · Cited by 5 · see citing works
Zhang, J., Xu, J., Zhang, J., Lin, Y., Li, J., Chen, D., Lin, W., Yang, C., & Yi, G. (2024) · Langmuir · doi:10.1021/acs.langmuir.4c00950 · Cited by 5 · see citing works
Hwang, J., Huang, S.-M., Lin, W., Liu, H., Chuang, C.-C., & Chiu, W.-H. (2021) · Minerals · doi:10.3390/min12010014 · Cited by 5 · see citing works
Shen, Y. Q., Xu, Z., Li, L., Yuan, W., Luo, M. B., & Xie, X. (2019) · New Journal of Chemistry · doi:10.1039/c9nj00729f · Cited by 5 · see citing works
2-Hydroxyoleic Acid as a Self-Assembly Inducer for Anti-Cancer Drug-Centered Nanoparticles
Antoniou, A. I., Nordio, G., Paolo, M. L. D., Colombo, E., Gaffuri, B., Polito, L., Amenta, A., Seneci, P., Via, L. D., Perdicchia, D., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16050722 · Cited by 4 · see citing works
Synthesis of Cross‐Linked Block Copolymer Nanoassemblies and their Coating Application
Shao, G., Yu, Y., & Zhang, W. (2022) · Macromolecular Rapid Communications · doi:10.1002/marc.202100909 · Cited by 4 · see citing works
Multi-layered stimuli responsive DNA micelles for the stepwise controlled release of small molecules
Santiana, J. J., Sawant, S. S., Gomez, N., & Rouge, J. L. (2022) · Journal of Materials Chemistry B · doi:10.1039/d1tb02722k · Cited by 4 · see citing works
Fluorescein Isothiocyanate Labelled PCL‐PEG‐PCL Copolymer as Delivery System of Capsaicin
Ferrentino, N., Caputo, T. M., Cusano, A. M., Aliberti, A., Cusano, A., & Pappalardo, D. (2024) · ChemNanoMat · doi:10.1002/cnma.202400130 · Cited by 2 · see citing works
Hu, B., Chen, Y., Zhai, M., Li, M., Peng, Y., Xu, F., Zhang, Y., Liu, J., Shao, W., & Zhang, Q. (2025) · Iranian Polymer Journal · doi:10.1007/s13726-025-01499-7 · Cited by 2 · see citing works
Hydrogel-based bio-inks for 3D cellular microenvironments: design, challenges, and advances
Parihar, A., Prajapati, P., & Arya, N. (2026) · Academia Materials Science · doi:10.20935/acadmatsci8240 · Cited by 1 · see citing works
DESIGN AND SYNTHESIS OF DIFFERENT TYPES OF POLY(LACTIC ACID)/POLYLACTIDE COPOLYMERS
Albertsson, A., Varma, I. K., Lochab, B., Finne‐Wistrand, A., Sahu, S., & Kumar, K. (2022) · doi:10.1002/9781119767480.ch4 · Cited by 1 · see citing works
Banerjee, A., Biswas, S., & Das, A. (2026) · Polymer Chemistry · doi:10.1039/d5py01148e
Tayde, D., Pandey, R., Das, A., & Pramanik, S. K. (2026) · Organic & Biomolecular Chemistry · doi:10.1039/d6ob00954a
- Authors
- Fuoco, T., Pappalardo, D., & Finne-Wistrand, A.
- Affiliations
- KTH Royal Institute of Technology (SE)
- University of Sannio (IT)
- KTH Royal Institute of Technology , , ,
- Corresponding author
- Pappalardo, Daniela
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-09-07
- Volume
- 50
- Issue
- 18
- Pages
- 7052-7061
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2751146916
- Cited by
- 56
- References
- 28
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 8 · 2019: 9 · 2018: 1
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Macromolecules (publishedVersion, other-oa)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Funders
- FP7 People: Marie-Curie Actions (291795)
- Stiftelsen för Strategisk Forskning (RMA15-0010)
- VINNOVA (NA)
- Vetenskapsrådet (621-2013-3764)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- redox-responsive nanoparticles, disulfide cross-linking, polylactic acid, polyethylene glycol, glutathione, disulfide exchange, ring-opening copolymerization, pyridyl disulfide, flower-like nanoparticles, drug delivery, Nile red encapsulation, nanoparticle stability
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