The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Long-Circulating Au-TiO2Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer
Abstract
Although sonodynamic therapy (SDT) has emerged as a potential alternative to conventional photodynamic therapy, the low quantum yield of the sonosensitizer such as TiO 2 nanoparticles (NPs) is still a major concern. Here, we have developed hydrophilized Au-TiO 2 nanocomposites (HAu-TiO 2 NCs) as sonosensitizers for improved SDT. The physicochemical properties of HAu-TiO 2 NCs were thoroughly studied and compared with their counterparts without gold deposition. Upon exposure of HAu-TiO 2 NCs to ultrasound, a large quantity of reactive oxygen species (ROS) were generated, leading to complete suppression of tumor growth after their systemic administration in vivo. Overall, it was evident that the composites of gold with TiO 2 NPs significantly augmented the levels of ROS generation, implying their potential as SDT agents for cancer therapy.
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Cites
Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002
Cited by
Huang, P., Qian, X., Chen, Y., Yu, L., Lin, H., Wang, L., Zhu, Y., & Shi, J. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.6b11846 · Cited by 666
Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation
Zhu, P., Chen, Y., & Shi, J. (2018) · ACS Nano · doi:10.1021/acsnano.8b00999 · Cited by 572
Gong, F., Cheng, L., Yang, N., Betzer, O., Feng, L., Zhou, Q., Li, Y., Chen, R., Popovtzer, R., & Liu, Z. (2019) · Advanced Materials · doi:10.1002/adma.201900730 · Cited by 533
Ultrafine Titanium Monoxide (TiO1+x) Nanorods for Enhanced Sonodynamic Therapy
Wang, X., Zhong, X., Bai, L., Xu, J., Gong, F., Dong, Z., Yang, Z., Zeng, Z., Liu, Z., & Cheng, L. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10228 · Cited by 532
Ultrasound‐Activated Sensitizers and Applications
Lin, X., Song, J., Chen, X., & Yang, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201906823 · Cited by 501
Metadata
- Authors
- Deepagan, V. G., You, D. G., Um, W., Ko, H., Kwon, S., Choi, K. Y., Yi, G.-R., Lee, J. Y., Lee, D. S., Kim, K., Kwon, I. C., & Park, J. H.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-10-03
- Volume
- 16
- Issue
- 10
- Pages
- 6257-6264
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2522213855
- Cited by
- 402
- References
- 1
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Long-Circulating Au-TiO2Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer. https://app.cochat.ai/papers/10.1021/acs.nanolett.6b02547
- The paper
- Deepagan, V. G., You, D. G., Um, W., Ko, H., Kwon, S., Choi, K. Y., Yi, G.-R., Lee, J. Y., Lee, D. S., Kim, K., Kwon, I. C., & Park, J. H. (2016). Long-Circulating Au-TiO2Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer. Nano Letters. https://doi.org/10.1021/acs.nanolett.6b02547
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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