The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Ultrasmall Oxygen‐Deficient Bimetallic Oxide MnWOX Nanoparticles for Depletion of Endogenous GSH and Enhanced Sonodynamic Cancer Therapy
Abstract
Sonodynamic therapy (SDT) triggered by ultrasound (US) has attracted increasing attention owing to its abilities to overcome critical limitations including low tissue‐penetration depth and phototoxicity in photodynamic therapy. Herein, the design of a new type of sonosensitizer is revealed, namely, ultrasmall oxygen‐deficient bimetallic oxide MnWOX nanoparticles, for multimodal imaging‐guided enhanced SDT against cancer. As‐made MnWOX nanoparticles with poly(ethylene glycol) (PEG) modification show high physiological stability and biocompatibility. Interestingly, such MnWOX‐PEG nanoparticles exhibit highly efficient US‐triggered production of 1 O 2 and •OH, higher than that of previously reported sonosensitizers (e.g., protoporphyrin IX and titanium dioxide), because the oxygen‐deficient structure of MnWOX serves as an electron trap site to prevent electron–hole recombination. The glutathione depletion capability of MnWOX‐PEG can also further favor SDT‐triggered cancer cell killing. With efficient tumor homing as illustrated by computer tomography and magnetic resonance imaging, MnWOX‐PEG enables effective destruction of mouse tumors under US stimulation. After accomplishing its therapeutic functions, MnWOX‐PEG can be metabolized by the mouse body without any long‐term toxicity. Herein, a new type of sono‐sensitizing agent with high SDT efficacy, multimodal imaging functions, and rapid clearance is presented, an agent which is promising for noninvasive SDT cancer treatment.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nanoparticles in Photodynamic Therapy
Lucky, S. S., Soo, K. C., & Zhang, Y. (2015) · Chemical Reviews · doi:10.1021/cr5004198 · Cited by 2,980
Functional Nanomaterials for Phototherapies of Cancer
Cheng, L., Wang, C., Feng, L., Yang, K., & Liu, Z. (2014) · Chemical Reviews · doi:10.1021/cr400532z · Cited by 2,425
Self-citationNanotechnology for Multimodal Synergistic Cancer Therapy
Fan, W., Yung, B., Huang, P., & Chen, X. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00258 · Cited by 1,791
Murdoch, M., Waterhouse, G. I. N., Nadeem, M. A., Metson, J. B., Keane, M. A., Howe, R. F., Llorca, J., & Idriss, H. (2011) · Nature Chemistry · doi:10.1038/nchem.1048 · Cited by 1,224
Cheng, L., Liu, J., Gu, X., Gong, H., Shi, X., Liu, T., Wang, C., Wang, X., Liu, G., Xing, H., et al. (2014) · Advanced Materials · doi:10.1002/adma.201304497 · Cited by 1,108
Self-citationQian, X., Zheng, Y., & Chen, Y. (2016) · Advanced Materials · doi:10.1002/adma.201602012 · Cited by 882
Disulfide-Cleavage-Triggered Chemosensors and Their Biological Applications
Lee, M. H., Yang, Z., Lim, C. W., Lee, Y. H., Dongbang, S., Kang, C., & Kim, J. S. (2013) · Chemical Reviews · doi:10.1021/cr300358b · Cited by 821
Chen, H., Tian, J., He, W., & Guo, Z. (2015) · Journal of the American Chemical Society · doi:10.1021/ja511420n · Cited by 813
Huang, P., Qian, X., Chen, Y., Yu, L., Lin, H., Wang, L., Zhu, Y., & Shi, J. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.6b11846 · Cited by 666
Liu, Y., Zhen, W., Jin, L., Zhang, S., Sun, G., Zhang, T., Xu, X., Song, S., Wang, Y., Liu, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b01893 · Cited by 617
Research works printed but not linked: 2
- 10.1016/j.jallcom.2014.09.049 · doi:10.1016/j.jallcom.2014.09.049
- 10.1039/C5SC00423C · doi:10.1039/c5sc00423c
Cited by
Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121110 · Cited by 1,168
Multifunctional sonosensitizers in sonodynamic cancer therapy
Son, S., Kim, J. H., Wang, X., Zhang, C., Yoon, S. A., Shin, J., Sharma, A., Lee, M. H., Cheng, L., Wu, J., et al. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00648f · Cited by 1,150
Self-citationInorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
Self-citationUltrasound‐Activated Sensitizers and Applications
Lin, X., Song, J., Chen, X., & Yang, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201906823 · Cited by 501
Tan, X., Huang, J., Wang, Y., He, S., Jia, L., Zhu, Y., Pu, K., Zhang, Y., & Yang, X. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202102703 · Cited by 262
Metadata
- Authors
- Gong, F., Cheng, L., Yang, N., Betzer, O., Feng, L., Zhou, Q., Li, Y., Chen, R., Popovtzer, R., & Liu, Z.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2019-04-12
- Volume
- 31
- Issue
- 23
- Pages
- e1900730-e1900730
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2938932754
- Cited by
- 533
- References
- 38
- FWCI
- 23.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Funders
- National Natural Science Foundation of China (51525203, 51761145041, 51572180)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Ultrasmall Oxygen‐Deficient Bimetallic Oxide MnWOX Nanoparticles for Depletion of Endogenous GSH and Enhanced Sonodynamic Cancer Therapy. https://app.cochat.ai/papers/10.1002/adma.201900730
- The paper
- Gong, F., Cheng, L., Yang, N., Betzer, O., Feng, L., Zhou, Q., Li, Y., Chen, R., Popovtzer, R., & Liu, Z. (2019). Ultrasmall Oxygen‐Deficient Bimetallic Oxide MnWOX Nanoparticles for Depletion of Endogenous GSH and Enhanced Sonodynamic Cancer Therapy. Advanced Materials. https://doi.org/10.1002/adma.201900730
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
