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Cited by 487

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A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry

Open access
Baumann, Marcus, Moody, Thomas S., Smyth, Megan, Wharry, Scott·2020·Organic Process Research & Development
DOI 10.1021/acs.oprd.9b00524
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Abstract

Continuous flow manufacture is an innovative technology platform, which is gaining momentum within the pharmaceutical industry. The key advantages of continuous flow include faster and safer reactions, which can be more environmentally friendly, smaller footprint, better quality product, and critically, the ability to perform chemistry that is difficult or impossible to do in batch mode. Globally, significant efforts have been made to develop the manufacturing flexibility and robustness of processes used to produce chemicals in a continuous way, yet despite these scientific developments, a major challenge for industry is the established application of flow technology to commercially relevant examples. The identification of opportunities to apply flow solutions to current processes is also critical to the success of this new technology for pharmaceutical and fine chemical companies. This review highlights industrial hurdles and the importance of education and showcases recent (2018–2019) and relevant industrial examples where utilization of flow technology has been successfully performed.

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Cited by

Metadata

Authors
Baumann, M., Moody, T. S., Smyth, M., & Wharry, S.
Venue
Organic Process Research & Development
Publisher
American Chemical Society (ACS)
Published
2020-01-10
Volume
24
Issue
10
Pages
1802-1813
ISSN
  • 1083-6160 (ISSN-L)
  • 1520-586X
DOI
10.1021/acs.oprd.9b00524
OpenAlex
W3000043886
Cited by
487
References
2
FWCI
20.42
Type
journal article
Language
en
Open access
green
Licence

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