Hybrid gelatin hydrogels in nanomedicine applications
Abstract
Gelatin based hydrogels are often incorporated with supporting materials such as chitosan, poly(vinyl alcohol), alginate, carbon nanotubes, and hyaluronic acid. These hybrid materials are specifically of interest in diversified nanomedicine fields as they exhibit unique physicochemical properties, antimicrobial activity, biodegradability, and biocompatibility. The applications include drug delivery, wound healing, cell culture, and tissue engineering. This paper reviews the various up-to-date methods to fabricate gelatin-based hydrogels, including UV photo-cross-linking, electrospinning, and 3D bioprinting. This paper also includes physical, chemical, mechanical, and biocompatibility characterization studies of several hybrid gelatin hydrogels and discusses their relevance in nanomedicine based applications. Challenges associated with the fabrication of hybrid materials for nanotechnology implementation, specifically in nanomedicine development, are critically discussed, and some future recommendations are provided.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Gelatin has weaker mechanical strength and is much more thermosensitive, losing its structural integrity at body temperature unless chemically modified or crosslinked.
“However, due to the denaturation process, gelatin has weaker mechanical strength and is much more thermosensitive, meaning it loses its structural integrity at body temperature unless chemically modified or crosslinked [51,52].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [51]
Cites
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Yue, K., Trujillo-de Santiago, G., Alvarez, M. M., Tamayol, A., Annabi, N., & Khademhosseini, A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.045 · Cited by 3,146 · see citing works
Stimulus-responsive hydrogels: theory, modern advances, and applications
Koetting, M. C., Peters, J. T., Steichen, S. D., & Peppas, N. A. (2015) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2015.04.001 · Cited by 1,191 · see citing works
Tonsomboon, K., & Oyen, M. L. (2013) · Journal of the Mechanical Behavior of Biomedical Materials · doi:10.1016/j.jmbbm.2013.03.001 · Cited by 207 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
<scp>pH</scp> ‐responsive polymers for drug delivery: Trends and opportunities
Singh, J., & Nayak, P. (2023) · Journal of Polymer Science · doi:10.1002/pol.20230403 · Cited by 327 · see citing works
Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Salahuddin, B., Wang, S., Sangian, D., Aziz, S., & Gu, Q.
- Affiliations
- University of Wollongong (AU)
- Chinese Academy of Sciences (CN)
- Technische Universität Berlin (DE)
- The University of Queensland (AU)
- Corresponding author
- Aziz, Shazed
- Gu, Qi
- Venue
- ACS Applied Bio Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-03-09
- Volume
- 4
- Issue
- 4
- Pages
- 2886-2906
- ISSN
- 2576-6422 (ISSN-L)
- OpenAlex
- W3133811143
- Cited by
- 134
- References
- 3
- Citations by year
- 2026: 18 · 2025: 32 · 2024: 31 · 2023: 26 · 2022: 24 · 2021: 3
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Bio Materials (publishedVersion)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- Figshare (submittedVersion)
- Funders
- Chinese Academy of Sciences (XDA16020802, Y829F11102)
- National Key Research and Development Program of China (2018YFE0204403)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- gelatin hydrogel, hybrid hydrogels, nanomedicine, drug delivery, wound healing, tissue engineering, cell culture, electrospinning, 3D bioprinting, biocompatibility, antimicrobial activity, biodegradability, chitosan, polyvinyl alcohol, alginate, carbon nanotubes, hyaluronic acid
- MeSH terms
- Biocompatible Materials, Gelatin, Humans, Materials Testing, Particle Size, Hydrogels, Nanotechnology, Nanomedicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
