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Protein Corona Influences Cellular Uptake of Gold Nanoparticles by Phagocytic and Nonphagocytic Cells in a Size-Dependent Manner
Abstract
The interaction at nanobio is a critical issue in designing safe nanomaterials for biomedical applications. Recent studies have reported that it is nanoparticle-protein corona rather than bare nanoparticle that determines the nanoparticle-cell interactions, including endocytic pathway and biological responses. Here, we demonstrate the effects of protein corona on cellular uptake of different sized gold nanoparticles in different cell lines. The experimental results show that protein corona significantly decreases the internalization of Au NPs in a particle size- and cell type-dependent manner. Protein corona exhibits much more significant inhibition on the uptake of large-sized Au NPs by phagocytic cell than that of small-sized Au NPs by nonphagocytic cell. The endocytosis experiment indicates that different endocytic pathways might be responsible for the differential roles of protein corona in the interaction of different sized Au NPs with different cell lines. Our findings can provide useful information for rational design of nanomaterials in biomedical application.
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Walkey, C. D., & Chan, W. C. W. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15233e · Cited by 1,758
Cited by
Xiao, W., Wang, Y., Zhang, H., Liu, Y., Xie, R., He, X., Zhou, Y., Liang, L., & Gao, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120888 · Cited by 174
Ho, Y. T., Kamm, R. D., & Kah, J. C. Y. (2018) · Nanoscale · doi:10.1039/c8nr02393j · Cited by 102
Zhang, T., Tang, M., Yao, Y., Ma, Y., & Pu, Y. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s191689 · Cited by 89
Huang, K., Boerhan, R., Liu, C., & Jiang, G. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00726 · Cited by 74
Refining in vitro models for nanomaterial exposure to cells and tissues
Guggenheim, E. J., Milani, S., Röttgermann, P. J. F., Dusinska, M., Saout, C., Salvati, A., Rädler, J. O., & Lynch, I. (2018) · NanoImpact · doi:10.1016/j.impact.2018.02.008 · Cited by 36
Metadata
- Authors
- Cheng, X., Tian, X., Wu, A., Li, J., Tian, J., Chong, Y., Chai, Z., Zhao, Y., Chen, C., & Ge, C.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-09-14
- Volume
- 7
- Issue
- 37
- Pages
- 20568-20575
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2402706228
- Cited by
- 300
- References
- 1
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Cheng, X., Tian, X., Wu, A., Li, J., Tian, J., Chong, Y., Chai, Z., Zhao, Y., Chen, C., & Ge, C. (2015). Protein Corona Influences Cellular Uptake of Gold Nanoparticles by Phagocytic and Nonphagocytic Cells in a Size-Dependent Manner. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.5b04290
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
