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Cited by 36Nanoparticles: synthesis and applicationsGraphene and Nanomaterials ApplicationsImmunotoxicology and immune responses

Refining in vitro models for nanomaterial exposure to cells and tissues

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Guggenheim, Emily J., Milani, Silvia, Röttgermann, Peter J.F., Dusinska, Maria, Saout, Christelle, Salvati, Anna, Rädler, Joachim O., Lynch, Iseult·2018·NanoImpact
DOI 10.1016/j.impact.2018.02.008
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  • Researchers early on realized that the immense number of newly developed nanomaterials would make classical in vivo animal tests impossible due to time, money, and number of animals required.

    “This is mainly due to the fact that researchers early on realized that the immense number of newly developed nanomaterials would make it impossible to perform classical in vivo animal tests due to the amount of time, money, and number of animals required (Hartung and Sabbioni, 2011; Schrurs and Lison, 2012; Guggenheim et al., 2018).”

    From In Vitro research Reproducibility: Keeping up High Standards (2019) · cites this paper as Guggenheim et al., 2018

    The Introduction (page not available in our copy) says the growing range of nanomaterials makes extensive in vivo testing impossible because of expense, and it identifies costly 90-day animal exposures. It does not say that the number of animals required makes such testing impossible, or explicitly attribute the constraint to time as well as cost. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • In nanotoxicology, in vitro toxicity assays are the most frequently used approaches to assess potential hazardous effects of engineered nanomaterials.

    “In nanotoxicology, in vitro toxicity assays are the most frequently used approaches to assess potential hazardous effects of engineered nanomaterials (Guggenheim et al., 2018).”

    From In Vitro research Reproducibility: Keeping up High Standards (2019) · cites this paper as Guggenheim et al., 2018

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Authors
Guggenheim, E. J., Milani, S., Röttgermann, P. J. F., Dusinska, M., Saout, C., Salvati, A., Rädler, J. O., & Lynch, I.
Affiliations
  • University of Birmingham (GB)
  • Center for NanoScience (DE)
  • University of Namur (BE)
  • University of Groningen (NL)
Corresponding author
Lynch, Iseult
ORCID
Venue
NanoImpact
Publisher
Elsevier BV
Published
2018-04
Volume
10
Pages
121-142
ISSN
2452-0748 (ISSN-L)
DOI
10.1016/j.impact.2018.02.008
OpenAlex
W2791122469
Cited by
36
References
8
Citations by year
2025: 1 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 7 · 2019: 7
FWCI
2.15
Type
journal article
Language
en
Update notices
erratum (2021-01-01)
Open access
Licence
Locations
  • NanoImpact (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion, cc-by-nc-nd)
  • NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc-nd)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Funders
EU FP7 Capacities (INFRA-2010-262163)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
  • Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
nanomaterial exposure, in vitro model, nanoparticle toxicity, engineered nanomaterials, nanomaterial dispersion, cell culture protocols, standard operating procedures, in vitro-in vivo extrapolation, air-liquid interface exposure, 3D co-culture model, alternatives to animal testing

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