The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer
Abstract
A straightforward nanoprecipitating method was developed to prepare water dispersible curcumin (CCM)-loaded nanoscale zeolitic imidazolate framework-8 (CCM@NZIF-8) nanoparticles (NPs). The as-synthesized CCM@NZIF-8 NPs possess high drug encapsulation efficiency (88.2%), good chemical stability and fast drug release in tumor acidic microenvironments. Confocal laser scanning microscopy and cytotoxicity experiments reveal that NZIF-8 based nanocarriers promote the cellular uptake of CCM and result in higher cytotoxicity of CCM@NZIF-8 than that of free CCM toward HeLa cells. The in vivo anticancer experiments indicate that CCM@NZIF-8 NPs exhibit much higher antitumor efficacy than free CCM. This work highlights the potential of using nanoscale metal organic framworks (NMOFs) as a simple and stable platform for developing a highly efficient drug delivery system in cancer treatment.
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He, C., Lu, K., Liu, D., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098862 · Cited by 885
Tan, J. C., Bennett, T. D., & Cheetham, A. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003205107 · Cited by 552
Cited by
Metal–Organic Frameworks for Cell and Virus Biology: A Perspective
Riccò, R., Liang, W., Li, S., Gassensmith, J. J., Caruso, F., Doonan, C., & Falcaro, P. (2018) · ACS Nano · doi:10.1021/acsnano.7b08056 · Cited by 293
Ren, N., Liang, N., Dong, M., Feng, Z., Meng, L., Sun, C., Wang, A., Yu, X., Wang, W., Xie, J., et al. (2022) · Small · doi:10.1002/smll.202202485 · Cited by 44
Rahmani, A., Maleki, A., Jafari, R., Rezaeejam, H., & Nadri, S. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00789e · Cited by 10
Metadata
- Authors
- Zheng, M., Liu, S., Guan, X., & Xie, Z.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-09-30
- Volume
- 7
- Issue
- 40
- Pages
- 22181-22187
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2291003829
- Cited by
- 247
- References
- 2
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zheng, M., Liu, S., Guan, X., & Xie, Z. (2015). One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.5b04315
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