Cited by 10Nanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryRadiation Therapy and Dosimetry

A multifunctional curcumin–Fe 3 O 4 @ZIF-8 nanoformulation as a T 2 MRI contrast agent and pH-responsive theranostic platform for targeted ROS generation, radiosensitization, and triple-negative breast cancer treatment

Rahmani, Ali, Maleki, Aziz, Jafari, Rahim, Rezaeejam, Hamed, Nadri, Samad·2025·Journal of Materials Chemistry B

Abstract

, underscoring its radiosensitization capabilities. Cell cycle analysis revealed G2/M-phase arrest, contributing to impaired cancer cell proliferation. Apoptosis assays confirmed a significant increase in early and late apoptotic populations, while real-time PCR analysis showed significant downregulation of anti-apoptotic BCL-xL and cyclin D1 genes with considerable upregulation of pro-apoptotic BAX, thus reinforcing the mechanism of tumor suppression. This triple-action theranostic system surpasses conventional chemotherapy and standalone MRI contrast agents by combining precision imaging with targeted therapy, offering transformative advancement in TNBC treatment.

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Crossref · 10.1039/d5tb00789e

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92 of 92 references verified0 citation errors · 0 not checkable

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Authors
Rahmani, A., Maleki, A., Jafari, R., Rezaeejam, H., & Nadri, S.
Affiliations
Zanjan University of Medical Sciences (IR)
Corresponding author
Nadri, Samad
Venue
Journal of Materials Chemistry B
Published
2025
Volume
13
Issue
42
Pages
13805-13829
ISSN
  • 2050-750X (ISSN-L)
  • 2050-7518
OpenAlex
W4414886212
Cited by
10
References
92
Citations by year
2026: 8 · 2025: 2
FWCI
2.45
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Materials Chemistry B (publishedVersion)
  • PubMed (publishedVersion)
Funders
Zanjan University of Medical Sciences (A-12-892-38)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
Keywords
curcumin, T2 MRI contrast agents, theranostics, pH-responsive drug delivery, reactive oxygen species generation, radiosensitization, triple-negative breast cancer, G2/M cell cycle arrest, apoptosis, Bcl-xL, cyclin D1, Bax
MeSH terms
Theranostic Nanomedicine, Metal-Organic Frameworks, Animals, Antineoplastic Agents, Cell Survival, Contrast Media, Curcumin, Drug Screening Assays, Antitumor, Female, Humans, Hydrogen-Ion Concentration, Imidazoles, Magnetic Resonance Imaging, Particle Size, Radiation-Sensitizing Agents, Apoptosis, Reactive Oxygen Species, Cell Line, Tumor, Cell Proliferation, Mice, Triple Negative Breast Neoplasms

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