The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Antibacterial and Anti-Inflammatory pH-Responsive Tannic Acid-Carboxylated Agarose Composite Hydrogels for Wound Healing
Abstract
pH-sensitive hydrogels play an important role in controlled drug release applications and have the potential to impact the management of wounds. In this study, we report the fabrication of novel carboxylated agarose/tannic acid hydrogel scaffolds cross-linked with zinc ions for the pH-controlled release of tannic acid. The resulting hydrogels exhibited negligible release of tannic acid at neutral and alkaline pH and sustained release at acidic pH, where they also displayed maximum swelling. The hydrogels also displayed favorable antibacterial and anti-inflammatory properties, and a lack of cytotoxicity toward 3T3 fibroblast cell lines. In simulated wound assays, significantly greater cell migration and proliferation was observed for cells exposed to tannic acid hydrogel extracts. In addition, the tannic acid hydrogels were able to suppress NO production in stimulated human macrophages in a concentration-dependent manner, indicating effective anti-inflammatory activity. Taken together, the cytocompatibility, antibacterial, and anti-inflammatory characteristics of these novel pH-sensitive hydrogels make them promising candidates for wound dressings.
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Citations
Cites
pH- and ion-sensitive polymers for drug delivery
Yoshida, T., Lai, T. C., Kwon, G. S., & Sako, K. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.821978 · Cited by 367
Cited by
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Mussel-inspired hydrogels: From design principles to promising applications
Zhang, C., Wu, B., Zhou, Y., Zhou, F., Liu, W., & Wang, Z. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00849g · Cited by 653
Kaczmarek, B. (2020) · Materials · doi:10.3390/ma13143224 · Cited by 624
Tannic acid: a crosslinker leading to versatile functional polymeric networks: a review
Chen, C., Yang, H., Yang, X., & Ma, Q. (2022) · RSC Advances · doi:10.1039/d1ra07657d · Cited by 561
Hydrogels as Drug Delivery Systems: A Review of Current Characterization and Evaluation Techniques
Vigata, M., Meinert, C., Hutmacher, D. W., & Bock, N. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121188 · Cited by 544
Metadata
- Authors
- Ninan, N., Forget, A., Shastri, V. P., Voelcker, N. H., & Blencowe, A.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-10-14
- Volume
- 8
- Issue
- 42
- Pages
- 28511-28521
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2527719646
- Cited by
- 676
- References
- 1
- FWCI
- 11.34
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
