The DOI matches its Crossref record; 164 of the 164 references it cites were found in a registry or an index.
Hydrogels as Drug Delivery Systems: A Review of Current Characterization and Evaluation Techniques
Open accessAbstract
Owing to their tunable properties, controllable degradation, and ability to protect labile drugs, hydrogels are increasingly investigated as local drug delivery systems. However, a lack of standardized methodologies used to characterize and evaluate drug release poses significant difficulties when comparing findings from different investigations, preventing an accurate assessment of systems. Here, we review the commonly used analytical techniques for drug detection and quantification from hydrogel delivery systems. The experimental conditions of drug release in saline solutions and their impact are discussed, along with the main mathematical and statistical approaches to characterize drug release profiles. We also review methods to determine drug diffusion coefficients and in vitro and in vivo models used to assess drug release and efficacy with the goal to provide guidelines and harmonized practices when investigating novel hydrogel drug delivery systems.
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Cites
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Cited by
Krishnakumar, I. M., Jaja-Chimedza, A., Joseph, A., Balakrishnan, A., Maliakel, B., & Swick, A. (2022) · Journal of Nutritional Science · doi:10.1017/jns.2022.72 · Cited by 70
Yadav, P., Warkar, S. G., & Kumar, A. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146662 · Cited by 13
Hybrid Multifunctional Nanomaterials for Diagnostic and Therapeutic Applications
Lagopati, N., Efstathopoulos, E. P., Veroutis, D., Katifelis, H., Theocharous, G., Pantelis, P., Evangelou, K., Gorgoulis, V. G., & Gazouli, M. (2022) · Nanotechnology in the Life Sciences · doi:10.1007/978-3-031-12658-1_17 · Cited by 6
Metadata
- Authors
- Vigata, M., Meinert, C., Hutmacher, D. W., & Bock, N.
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2020-12-07
- Volume
- 12
- Issue
- 12
- Pages
- 1188
- ISSN
- 1999-4923 (ISSN-L)
- OpenAlex
- W3111367879
- Cited by
- 544
- References
- 164
- FWCI
- 13.76
- Type
- journal article
- Language
- en
- Open access
- gold
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- Vigata, M., Meinert, C., Hutmacher, D. W., & Bock, N. (2020). Hydrogels as Drug Delivery Systems: A Review of Current Characterization and Evaluation Techniques. Pharmaceutics. https://doi.org/10.3390/pharmaceutics12121188
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
