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PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy
Abstract
The integration of photothermal therapy (PTT) with radiation therapy (RT) in a single nanoscale platform is believed to have considerable potential for cancer therapy. In this work, the rationally designed PEGylated Au@Pt nanodendrites (NDs) have been developed as a novel X-ray computed tomography (CT) and PTT/RT enhanced theranostic agent for cancer therapy. The absorption of Au@Pt NDs was turned to the near-infrared region with the growth of Pt nanobranches and thus enhances the efficacy of PTT. Furthermore, because of the high atomic number (high Z) of Au as well as Pt, Au@Pt NDs significantly enhanced lethal effects of RT by inducing a highly localized radiation dose within cancer cells. More importantly, the combination of Au@Pt ND-enhanced RT with PTT suppressed cancer cell growth more efficiently than that RT or PTT alone did, indicating a synergistic effect. Meanwhile, the Au@Pt NDs also possess significant CT imaging signal enhancement that has the potential to guide PTT/RT for cancers. The integrated strategy significantly improved CT and PTT/RT of cancer cells with mild laser and radiation. Because of these advantages, Au@Pt NDs have become appealing and effective agents for cancer theranostic.
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Citations
Cited by
Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy
Song, G., Cheng, L., Chao, Y., Yang, K., & Liu, Z. (2017) · Advanced Materials · doi:10.1002/adma.201700996 · Cited by 771
X-ray-activated nanosystems for theranostic applications
Chen, X., Song, J., Chen, X., & Yang, H. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00921j · Cited by 401
Graphene‐Based Smart Platforms for Combined Cancer Therapy
Gu, Z., Zhu, S., Yan, L., Zhao, F., & Zhao, Y. (2019) · Advanced Materials · doi:10.1002/adma.201800662 · Cited by 334
Wang, M., Chang, M., Chen, Q., Wang, D., Li, C., Hou, Z., Lin, J., Jin, D., & Xing, B. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120093 · Cited by 322
Research progress on nano-sensitizers for enhancing the effects of radiotherapy
Zhang, Y., Han, X., Liu, Y., Wang, S., Han, X., & Cheng, C. (2022) · Materials Advances · doi:10.1039/d2ma00094f · Cited by 44
Metadata
- Authors
- Liu, X., Zhang, X., Zhu, M., Lin, G., Liu, J., Zhou, Z., Tian, X., & Pan, Y.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-12-22
- Volume
- 9
- Issue
- 1
- Pages
- 279-285
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2565720499
- Cited by
- 164
- References
- 0
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy. https://app.cochat.ai/papers/10.1021/acsami.6b15183
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- Liu, X., Zhang, X., Zhu, M., Lin, G., Liu, J., Zhou, Z., Tian, X., & Pan, Y. (2017). PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.6b15183
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