The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Multifunctional Nanoplatform Based on Black Phosphorus Quantum Dots for Bioimaging and Photodynamic/Photothermal Synergistic Cancer Therapy
Abstract
A multifunctional nanoplatform based on black phosphorus quantum dots (BPQDs) was developed for cancer bioimaging and combined photothermal therapy (PTT) and photodynamic therapy (PDT). BPQDs were functionalized with PEG chains to achieve improved biocompatibility and physiological stability. The as-prepared nanoparticles exhibite prominent near-infrared (NIR) photothermal and red-light-triggered photodynamic properties. The combined therapeutic application of PEGylated BPQDs were then performed in vitro and in vivo. The results demonstrate that the combined phototherapy significantly promote the therapeutic efficacy of cancer treatment in comparison with PTT or PDT alone. BPQDs could also serve as the loading platform for fluorescent molecules, allowing reliable imaging of cancer cells. In addition, the low cytotoxicity and negligible side effects to main organs were observed in toxicity experiments. The theranostic characteristics of PEGylated BPQDs provide an uplifting potential for the future clinical applications.
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Cites
Light‐sensitive Intelligent Drug Delivery Systems†
Alvarez‐Lorenzo, C., Bromberg, L., & Concheiro, A. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2008.00530.x · Cited by 519
Cited by
Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies
Xie, J., Wang, Y., Choi, W., Jangili, P., Ge, Y., Xu, Y., Kang, J., Liu, L., Zhang, B., Xie, Z., et al. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01370f · Cited by 522
Black Phosphorus and its Biomedical Applications
Choi, J. R., Yong, K. W., Choi, J. Y., Nilghaz, A., Lin, Y., Xu, J., & Lu, X. (2018) · Theranostics · doi:10.7150/thno.22573 · Cited by 353
Metadata
- Authors
- Li, Y., Liu, Z., Hou, Y., Yang, G., Fei, X., Zhao, H., Guo, Y., Su, C., Wang, Z., Zhong, H., Zhuang, Z., & Guo, Z.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-07-20
- Volume
- 9
- Issue
- 30
- Pages
- 25098-25106
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2732051673
- Cited by
- 233
- References
- 1
- FWCI
- 11.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, Y., Liu, Z., Hou, Y., Yang, G., Fei, X., Zhao, H., Guo, Y., Su, C., Wang, Z., Zhong, H., Zhuang, Z., & Guo, Z. (2017). Multifunctional Nanoplatform Based on Black Phosphorus Quantum Dots for Bioimaging and Photodynamic/Photothermal Synergistic Cancer Therapy. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.7b05824
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