Light‐sensitive Intelligent Drug Delivery Systems†
Abstract
Drug delivery systems (DDS) capable of releasing an active molecule at the appropriate site and at a rate that adjusts in response to the progression of the disease or to certain functions/biorhythms of the organism are particularly appealing. Biocompatible materials sensitive to certain physiological variables or external physicochemical stimuli (intelligent materials) can be used for achieving this aim. Light-responsiveness is receiving increasing attention owing to the possibility of developing materials sensitive to innocuous electromagnetic radiation (mainly in the UV, visible and near-infrared range), which can be applied on demand at well delimited sites of the body. Some light-responsive DDS are of a single use (i.e. the light triggers an irreversible structural change that provokes the delivery of the entire dose) while others able to undergo reversible structural changes when cycles of light/dark are applied, behave as multi-switchable carriers (releasing the drug in a pulsatile manner). In this review, the mechanisms used to develop polymeric micelles, gels, liposomes and nanocomposites with light-sensitiveness are analyzed. Examples of the capability of some polymeric, lipidic and inorganic structures to regulate the release of small solutes and biomacromolecules are presented and the potential of light-sensitive carriers as functional components of intelligent DDS is discussed.
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This technique is commonly applied for controlled drug release.
“Therefore, this technique is commonly applied for controlled drug release [181,182].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [182]
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- Authors
- Alvarez‐Lorenzo, C., Bromberg, L., & Concheiro, A.
- Affiliations
- Universidade de Santiago de Compostela (ES)
- Massachusetts Institute of Technology (US)
- Corresponding author
- Alvarez‐Lorenzo, Carmen
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 2009-06-22
- Volume
- 85
- Issue
- 4
- Pages
- 848-860
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W2003770685
- Cited by
- 519
- References
- 88
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 24 · 2023: 17 · 2022: 24 · 2021: 38 · 2020: 35 · 2019: 30 · 2018: 36 · 2017: 34 · 2016: 45 · 2015: 45 · 2014: 36 · 2013: 42 · 2012: 36
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- light-responsive drug delivery, stimuli-responsive materials, photothermal drug release, polymeric micelles, liposomes, gels, nanocomposites, pulsatile drug release, near-infrared light, photothermal therapy
- MeSH terms
- Gels, Light, Liposomes, Micelles, Drug Delivery Systems, Nanocomposites
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