Cited by 519Hydrogels: synthesis, properties, applicationsNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

Light‐sensitive Intelligent Drug Delivery Systems†

Alvarez‐Lorenzo, Carmen, Bromberg, Lev, Concheiro, Angel·2009·Photochemistry and Photobiology

Abstract

Drug delivery systems (DDS) capable of releasing an active molecule at the appropriate site and at a rate that adjusts in response to the progression of the disease or to certain functions/biorhythms of the organism are particularly appealing. Biocompatible materials sensitive to certain physiological variables or external physicochemical stimuli (intelligent materials) can be used for achieving this aim. Light-responsiveness is receiving increasing attention owing to the possibility of developing materials sensitive to innocuous electromagnetic radiation (mainly in the UV, visible and near-infrared range), which can be applied on demand at well delimited sites of the body. Some light-responsive DDS are of a single use (i.e. the light triggers an irreversible structural change that provokes the delivery of the entire dose) while others able to undergo reversible structural changes when cycles of light/dark are applied, behave as multi-switchable carriers (releasing the drug in a pulsatile manner). In this review, the mechanisms used to develop polymeric micelles, gels, liposomes and nanocomposites with light-sensitiveness are analyzed. Examples of the capability of some polymeric, lipidic and inorganic structures to regulate the release of small solutes and biomacromolecules are presented and the potential of light-sensitive carriers as functional components of intelligent DDS is discussed.

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Crossref · 10.1111/j.1751-1097.2008.00530.x

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88 of 88 references verified0 citation errors · 0 not checkable

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  • This technique is commonly applied for controlled drug release.

    “Therefore, this technique is commonly applied for controlled drug release [181,182].”

    From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [182]

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Authors
Alvarez‐Lorenzo, C., Bromberg, L., & Concheiro, A.
Affiliations
  • Universidade de Santiago de Compostela (ES)
  • Massachusetts Institute of Technology (US)
Corresponding author
Alvarez‐Lorenzo, Carmen
Venue
Photochemistry and Photobiology
Publisher
Wiley
Published
2009-06-22
Volume
85
Issue
4
Pages
848-860
ISSN
  • 0031-8655 (ISSN-L)
  • 1751-1097
OpenAlex
W2003770685
Cited by
519
References
88
Citations by year
2026: 14 · 2025: 17 · 2024: 24 · 2023: 17 · 2022: 24 · 2021: 38 · 2020: 35 · 2019: 30 · 2018: 36 · 2017: 34 · 2016: 45 · 2015: 45 · 2014: 36 · 2013: 42 · 2012: 36
FWCI
1.40
Type
journal article
Language
en
Open access
closed
Locations
  • Photochemistry and Photobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
light-responsive drug delivery, stimuli-responsive materials, photothermal drug release, polymeric micelles, liposomes, gels, nanocomposites, pulsatile drug release, near-infrared light, photothermal therapy
MeSH terms
Gels, Light, Liposomes, Micelles, Drug Delivery Systems, Nanocomposites

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