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Highly Sensitive and Reproducible SERS Sensor for Biological pH Detection Based on a Uniform Gold Nanorod Array Platform
Open accessAbstract
Conventional research on surface-enhanced Raman scattering (SERS)-based pH sensors often depends on nanoparticle aggregation, whereas the variability in nanoparticle aggregation gives rise to poor repeatability in the SERS signal. Herein, we fabricated a gold nanorod array platform via an efficient evaporative self-assembly method. The platform exhibits great SERS sensitivity with an enhancement factor of 5.6 × 10 7 and maintains excellent recyclability and reproducibility with relative standard deviation (RSD) values of less than 8%. On the basis of the platform, we developed a highly sensitive bovine serum albumin (BSA)-coated 4-mercaptopyridine (4-MPy)-linked (BMP) SERS-based pH sensor to report pH ranging from pH 3.0 to pH 8.0. The intensity ratio variation of 1004 and 1096 cm –1 in 4-MPy showed excellent pH sensitivity, which decreased as the surrounding pH increased. Furthermore, this BMP SERS-based pH sensor was employed to measure the pH value in C57BL/6 mouse blood. We have demonstrated that the pH sensor has great advantages such as good stability, reliability, and accuracy, which could be extended for the design of point-of-care devices.
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The SERS peak intensities of 4-MPy at 1008 cm−1 and 1100 cm−1 vary during protonation or deprotonation, corresponding to pyridine ring breathing vibration and carbon-sulfur bond, respectively.
“The peak intensity at 1008 cm 1 and 1100 cm 1 varies during protonation or deprotonation process, corresponding to pyridine ring breathing vibration and carbon -sulfur bond, respectively. [34,35]”
From Multiplex Cellular Microenvironment Detection Based on Surface-Enhanced Raman Scattering Patch (2025) · cites this paper as [35]
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References 40 · Cited by 113
Research works printed but not linked: 1
- 10.1021/ac981131+ · DOI
Metadata
- Authors
- Bi, L., Wang, Y., Yang, Y., Li, Y., Mo, S., Zheng, Q., & Chen, L.
- Affiliations
- Binzhou Medical University (CN)
- Yantai Institute of Coastal Zone Research (CN)
- Corresponding author
- Zheng, Qingyin
- Chen, Lingxin
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-04-17
- Volume
- 10
- Issue
- 18
- Pages
- 15381-15387
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2799833708
- Cited by
- 113
- References
- 40
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 17 · 2023: 4 · 2022: 18 · 2021: 18 · 2020: 15 · 2019: 15 · 2018: 3
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- green
- ir.yic.ac.cn
- Licence
- cc-by-nc-sa
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Knowledge Repository of Yantai Institute of Coastal Zone Research, CAS (Yantai Institute of Coastal Zone Research) (submittedVersion)
- Knowledge Repository of Yantai Institute of Coastal Zone Research, CAS (Yantai Institute of Coastal Zone Research) (submittedVersion, cc-by-nc-sa)
- Funders
- Shandong Province (J16LK10)
- National Natural Science Foundation of China (51401031, 81530030, 81573393, 21575159, 21605005)
- Chinese Academy of Sciences (CXJJ-17-Q148)
- Topics
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Plasmonic and Surface Plasmon Research
- Keywords
- surface-enhanced Raman scattering, gold nanorod arrays, evaporation-induced self-assembly, 4-mercaptopyridine, bovine serum albumin, nanoparticle aggregation, signal reproducibility, blood pH measurement, point-of-care devices
- MeSH terms
- Animals, Gold, Hydrogen-Ion Concentration, Mice, Inbred C57BL, Spectrum Analysis, Raman, Reproducibility of Results, Nanotubes, Mice, Metal Nanoparticles
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