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Nanoscale Gambogic Acid Liposomes for NIR-II Photoacoustic Imaging and Photothermal-Chemo Tumor Therapy

Yang, Yafeng, Chen, Kai, He, Xiaotong, Han, Hui, Li, Lei, Li, Meixing, Shen, Qingming·2024·ACS Applied Nano Materials
DOI 10.1021/acsanm.4c02918
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Abstract

Photothermal therapy (PTT) has attracted widespread interest due to its precise spatiotemporal selectivity and minimal noninvasiveness. However, it is still limited by the depth of light penetration, thermoresistance of tumors, and limitations of monotherapeutic modalities. In this study, we synthesized an organometallic photosensitizer (NiPTZ) with the capability of photothermal conversion in the second near-infrared (NIR-II) range, making it a promising candidate for photoacoustic imaging (PAI)-guided PTT. To mitigate the impact of excessive heat shock proteins (HSPs) expression caused by thermal damage on PTT efficacy, we developed nanoscale thermosensitive (gambogic acid) GA-liposomes Lip(NiPTZ-GA) by self-assembling PEGylated gambogic acid (GA, HSP90 inhibitor), NiPTZ, DPPC, and DSPE–PEG 2000 . Upon the NIR-II light irradiation, Lip(NiPTZ-GA) generated high temperatures and underwent dissociation to release NiPTZ, enabling efficient PTT and PAI. GA-PEG suppressed heat-induced overexpression of HSP90 successfully, while achieving synergistic chemotherapy. Downregulation of HSP90 could reduce the thermoresistance of tumors and enhance the therapeutic efficiency of PTT. This study presents an innovative multifunctional liposome platform for NIR-II PAI-guided enhanced PTT combined with chemotherapy.

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Metadata

Authors
Yang, Y., Chen, K., He, X., Han, H., Li, L., Li, M., & Shen, Q.
Venue
ACS Applied Nano Materials
Publisher
American Chemical Society (ACS)
Published
2024-07-24
Volume
7
Issue
15
Pages
17688-17696
ISSN
2574-0970
DOI
10.1021/acsanm.4c02918
Cited by
12
References
2
Language
en
Licence
Funders
  • Graduate Research and Innovation Projects of Jiangsu Province (KYCX22_1006)
  • Qinglan Project of Jiangsu Province of China
  • Natural Science Foundation of Jiangsu Province (BK20221326)
  • Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (20KJA430012)

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Yang, Y., Chen, K., He, X., Han, H., Li, L., Li, M., & Shen, Q. (2024). Nanoscale Gambogic Acid Liposomes for NIR-II Photoacoustic Imaging and Photothermal-Chemo Tumor Therapy. ACS Applied Nano Materials. https://doi.org/10.1021/acsanm.4c02918