NIR-II fluorescence imaging guided tumor-specific NIR-II photothermal therapy enhanced by starvation mediated thermal sensitization strategy
Abstract
Photothermal therapy (PTT) is hampered by limited light penetration depth and cell thermoresistance induced by over-expressed heat shock proteins (HSPs). Herein, we proposed a tumor-specific enhanced NIR-II PTT through the starvation mediated thermal sensitization strategy. A semiconducting polymer with superior NIR-II fluorescence imaging (FI) performance and NIR-II PTT efficacy was synthesized and encapsulated into folate modified liposomes, together with a glycolysis inhibitor, 2-deoxy-d-glucose (2DG). Upon specifically targeting folate receptors and guidance of NIR-II FI, spatiotemporal 2DG release could be achieved by the trigger of NIR-II photothermal effect. The released 2DG could not only deplete the energy supply of tumor cells by inhibiting tumor anaerobic glycolysis, but also decrease the ATP levels and hamper the production of HSPs, ultimately enhancing the tumor thermal sensitivity toward PTT. Owing to the sensitization effect of 2DG, tumor cells with overexpressed folate receptors could be significantly damaged by NIR-II PTT with an enhanced therapeutic efficiency. The work provided a promising strategy for specific starvation/NIR-II PTT synergistic therapy towards tumors.
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Combining the diketopyrrolopyrrole donor and the triazole [4,5-g]-quinoxaline (TTQ) acceptor leads to a new narrow band gap conjugated polymer (DPQ).
“Combining the diketopyrrolopyrrole donor and the triazole [4,5-g]-quinoxaline (TTQ) acceptor leads to a new narrow band gap conjugated polymer (DPQ).172”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [172]
DPQ coencapsulated with glycolysis inhibitor, 2DG, in liposomes showed absorption at 1064 nm and bright fluorescence emission peaking at 1300 nm.
“DPQ coencapsulated with glycolysis inhibitor, 2DG, in liposomes showed absorption at 1064 nm and bright fluorescence emission peaking at 1300 nm.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [172]
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- Authors
- Dai, Y., Sun, Z., Zhao, H., Qi, D., Li, X., Gao, D., Li, M., Fan, Q., Shen, Q., & Huang, W.
- Affiliations
- Nanjing University of Posts and Telecommunications (CN)
- Simcere Pharmaceutical (China) (CN)
- Northwestern Polytechnical University (CN)
- Corresponding author
- Shen, Qingming
- Huang, Wei
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 275
- Pages
- 120935
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W3168779724
- Cited by
- 117
- References
- 46
- Citations by year
- 2026: 7 · 2025: 21 · 2024: 27 · 2023: 24 · 2022: 34 · 2021: 4
- FWCI
- 6.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- NIR-II photothermal therapy, NIR-II fluorescence imaging, 2-deoxyglucose, glycolysis inhibition, heat shock proteins, folate receptor targeting, semiconducting polymers, ATP depletion, tumor energy metabolism
- MeSH terms
- Photothermal Therapy, Humans, Neoplasms, Phototherapy, Polymers, Cell Line, Tumor, Nanoparticles, Optical Imaging
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