Fibroblasts slow conduction velocity in a reconstituted tissue model of fibrotic cardiomyopathy
Open accessAbstract
Myocardial function deteriorates over the course of fibrotic cardiomyopathy, because of electrophysiological and mechanical effects of myofibroblasts that are not completely understood. Although a range of experimental model systems and associated theoretical treatments exist at the levels of isolated cardiomyocytes and planar cocultures of myofibroblasts and cardiomyocytes, interactions between these cell types at the tissue level are less clear. We studied these interactions through an engineered heart tissue (EHT) model of fibrotic myocardium and a mathematical model of the effects of cellular composition on EHT impulse conduction velocity. The EHT model allowed for modulation of cardiomyocyte and myofibroblast volume fractions, and observation of cell behavior in a three-dimensional environment that is more similar to native heart tissue than is planar cell culture. The cardiomyocyte and myofibroblast volume fractions determined the retardation of impulse conduction (spread of the action potential) in EHTs as measured by changes of the fluorescence of the Ca 2+ probe, Fluo-2. Interpretation through our model showed retardation far in excess of predictions by homogenization theory, with conduction ceasing far below the fibroblast volume fraction associated with steric percolation. Results point to an important multiscale structural role of myofibroblasts in attenuating impulse conduction in fibrotic cardiomyopathy.
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Myofibroblast population plays a significant role in reducing impulse conduction velocity in fibrotic cardiac tissue.
“The results demonstrated a significant role of myofibroblast population in reducing impulse conduction velocity in the fibrotic cardiac tissue (Fig. 6 B) [309].”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [309]
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- Authors
- Spencer, T. M., Blumenstein, R. F., Pryse, K. M., Lee, S.-L., Glaubke, D. A., Carlson, B. E., Elson, E. L., & Genin, G. M.
- Affiliations
- Washington University in St. Louis (US)
- University of Michigan (US)
- Corresponding author
- Genin, Guy M.
- Venue
- ACS Biomaterials Science & Engineering
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-10-31
- Volume
- 3
- Issue
- 11
- Pages
- 3022-3028
- ISSN
- 2373-9878 (ISSN-L)
- PMC
- PMC6527425
- OpenAlex
- W2532467450
- Cited by
- 23
- References
- 52
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- ACS Biomaterials Science & Engineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (DGE-1143954)
- U.S. Department of Health and Human Services (R01HL109505)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- myofibroblasts, fibroblasts, engineered heart tissue, action potential propagation, volume fraction, homogenization theory, multiscale modeling, calcium imaging
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