Cited by 12Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryIntraocular Surgery and Lenses

PLA-PEG micelles loaded with a classic vasodilator for oxidative cataract prevention

Xu, Lu, Qiu, Wen-Xiu, Liu, Wen-Long, Zhang, Chi, Zou, Mei-Zhen, Sun, Yun-Xia, Zhang, Xian-Zheng·2019·ACS Biomaterials Science & Engineering

Abstract

The only treatment for cataract in clinic is the clouded lens removal combined with artificial lens implantation. In this study, nifedipine (NFP), a classic vasodilator, was loaded in a U.S. FDA-approved polymer PLA-PEG to form NFP-loaded PLA-PEG micelles as a novel eye drop to prevent oxidative cataract formation and progression at the early stage. The NFP-loaded PLA-PEG micelles not only showed satisfactory biocompatibility and bioavailability, but also efficiently improved the anticataract ability through the inhibition of extracellular calcium ions influx. This study may provide a new insight into the development of cataract treatment.

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Crossref · 10.1021/acsbiomaterials.8b01089

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23 of 23 references verified0 citation errors · 0 not checkable

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  • NFP-loaded PLA-PEG micelles demonstrated satisfactory biocompatibility and bioavailability while enhancing anticataract efficacy through inhibiting extracellular calcium ion influx.

    “The NFP-loaded PLA-PEG micelles demonstrated satisfactory biocompatibility and bioavailability while availably enhancing anticataract efficacy through inhibiting the extracellular calcium ion influx.”

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Authors
Xu, L., Qiu, W.-X., Liu, W.-L., Zhang, C., Zou, M.-Z., Sun, Y.-X., & Zhang, X.-Z.
Affiliations
  • Wuhan University (CN)
  • Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, People’s Republic of China
Corresponding author
Zhang, Xian-Zheng
Venue
ACS Biomaterials Science & Engineering
Published
2019-01-09
Volume
5
Issue
2
Pages
407-412
ISSN
2373-9878 (ISSN-L)
OpenAlex
W2908847928
Cited by
12
References
23
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 2 · 2020: 3 · 2019: 2
FWCI
0.75
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Biomaterials Science & Engineering (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (51473126, 51690152)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Ophthalmology › Intraocular Surgery and Lenses
Keywords
cataract prevention, nifedipine, eye drops, calcium influx inhibition, drug delivery, biocompatibility, bioavailability

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