PLA-PEG micelles loaded with a classic vasodilator for oxidative cataract prevention
Abstract
The only treatment for cataract in clinic is the clouded lens removal combined with artificial lens implantation. In this study, nifedipine (NFP), a classic vasodilator, was loaded in a U.S. FDA-approved polymer PLA-PEG to form NFP-loaded PLA-PEG micelles as a novel eye drop to prevent oxidative cataract formation and progression at the early stage. The NFP-loaded PLA-PEG micelles not only showed satisfactory biocompatibility and bioavailability, but also efficiently improved the anticataract ability through the inhibition of extracellular calcium ions influx. This study may provide a new insight into the development of cataract treatment.
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NFP-loaded PLA-PEG micelles demonstrated satisfactory biocompatibility and bioavailability while enhancing anticataract efficacy through inhibiting extracellular calcium ion influx.
“The NFP-loaded PLA-PEG micelles demonstrated satisfactory biocompatibility and bioavailability while availably enhancing anticataract efficacy through inhibiting the extracellular calcium ion influx.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [155]
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- Authors
- Xu, L., Qiu, W.-X., Liu, W.-L., Zhang, C., Zou, M.-Z., Sun, Y.-X., & Zhang, X.-Z.
- Affiliations
- Wuhan University (CN)
- Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, People’s Republic of China
- Corresponding author
- Zhang, Xian-Zheng
- Venue
- ACS Biomaterials Science & Engineering
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-01-09
- Volume
- 5
- Issue
- 2
- Pages
- 407-412
- ISSN
- 2373-9878 (ISSN-L)
- OpenAlex
- W2908847928
- Cited by
- 12
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 2 · 2020: 3 · 2019: 2
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Biomaterials Science & Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (51473126, 51690152)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Ophthalmology › Intraocular Surgery and Lenses
- Keywords
- cataract prevention, nifedipine, eye drops, calcium influx inhibition, drug delivery, biocompatibility, bioavailability
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