Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach
Bassi, Zuni I., Fillmore, Martin C., Miah, Afjal H., Chapman, Trevor D., Maller, Claire, Roberts, Emma J., Davis, Lauren C., Lewis, Darcy E. +9 more·2018·ACS Chemical Biology
Cited by (197)
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- From Degraders to Molecular Glues: New Ways of Breaking Down Disease‐Associated ProteinsYvonne A. Nagel, Adrian Britschgi, Antonio Ricci · 2021 · Wiley eBooks
- PROTAC-mediated Target Degradation: A Paradigm Changer in Drug Discovery?Philipp M. Cromm, Craig M. Crews, Hilmar Weinmann · 2020 · Royal Society of Chemistry eBooks
- Determination of key functional structures of an amorphous VHL-based SMARCA2 PROTACDaria Torodii, Jacob Brian Holmes, Manuel Cordova, Pinelopi Moutzouri, Lotte van Beek, Fredrik Edfeldt, Erik Malmerberg, Stig D. Friis, Johan R. Johansson, Alexander G. Milbradt et al. · 2025 · Nature Communications
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- Exploration of bromodomain ligand-linker conjugation sites for efficient CBP/p300 heterobifunctional degrader activityPraveen Kumar Tiwari, Sai Reddy Doda, Raghu Vannam, Manish S. Hudlikar, Drew A. Harrison, Samuel Ojeda, Sumit Rai, Ann-Sophie Koglin, Angelique Gilbert, Christopher J. Ott · 2024 · Bioorganic & Medicinal Chemistry Letters
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- Advantages of PROTACs in achieving selective degradation of homologous protein familiesLuxi Yang, Xinfei Mao, Jingyi Zhang, Jing Shu, Wenhai Huang, Xiaowu Dong, Yinqiao Chen, Mingfei Wu · 2026 · Beilstein Journal of Organic Chemistry
- Therapeutic approaches targeting oncogenic proteins in myeloid leukemia: challenges and perspectivesXing Yi Yan, Yuan Yuan Kang, Ze Yan Zhang, Ping Cheong Huang, Chang Yang, Hua Naranmandura · 2024 · Expert Opinion on Therapeutic Targets
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- Chemical Targeting of Histone AcetyltransferasesQi Liu, Aimee L. Qi, Adam David Durbin, Jun Qi · 2024 · Royal Society of Chemistry eBooks
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- Targeted Protein Degradation by Proteolysis Targeting ChimerasWu Du · 2022
- Application of PROTAC Technology in Drug DevelopmentPrashant S. Kharkar, Atul L. Jadhav · 2022 · Methods and principles in medicinal chemistry
- Broadening the horizon: The promise of PROTACs in non-malignant disordersLiping Fu, Gongruixue Zeng, Yu Cao, Yueli He, Yaping Zhao, Chongmei Tian, Jinbai Chen, Hualin Feng, Jianjun Xi, Jingsong Shao et al. · 2026 · European Journal of Medicinal Chemistry
- Insights into the structure and evolution of the human SAGA complex by affinity-ligand purificationMylène Damilot, Thomas Schoeps, Làszlò Tora, Patrick Schultz, Luc Lebeau, Gábor Pápai, Adam Ben Shem · 2026 · Science Advances
- Targeted Protein Degradation Chemical ProbesCarles Galdeano, Xavier Barril · 2020 · Royal Society of Chemistry eBooks
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- Idegenerering i IT-bedrifter - åpenhet og nettverks betydning for idégenereringTony Andreas Liafjell · 2014 · NORA - Norwegian Open Research Archives
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- New Therapeutic Chemical Modalities: Compositions, Modes-of-action, and Drug DiscoveryEric Valeur · 2023 · Royal Society of Chemistry eBooks
- Targeting the Acetylation Reader Family: Bromodomain ProteinsMartin P. Schwalm, Atoosa Karimi Babaahmadi, Suzanne Z. Ackloo, Stefan Knapp · 2024 · Royal Society of Chemistry eBooks
- Drug Discovery for Chromatin Readers, Writers, Erasers, Remodelers and Epitranscriptomic Targets2024 · Royal Society of Chemistry eBooks
- Targeted Protein Degradation of MetalloenzymesConor O’Herin, Seth M. Cohen · 2025 · Wiley eBooks
- CDK8 Inhibition Releases the Muscle Differentiation Block in Fusion-Driven Alveolar RhabdomyosarcomaSusu Zhang, Kathleen L. Engel, Assil Fahs, Ara Jo, Clare F. Malone, Kenneth N. Ross, Marissa A. Just, Brian Guedes, Diyana Granum, Kristianne Michelle Oristian et al. · 2026 · Cancer Discovery
- Novel insights into the structure and evolution of the human SAGA complex by affinity-ligand purificationMylène Damilot, Thomas Schoeps, Làszlò Tora, Patrick Schultz, Luc Lebeau, Gábor Pápai, Adam Ben Shem · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 7 of Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockadeJinteng Li, Ye, Feng, Xu, Xiaojun, Peitao Xu, Wang, Peng, Zheng, Guan, Guiwen Ye, Yu, Wenhui, Zepeng Su, Lin, Jiajie et al. · 2023 · Figshare
- Additional file 6 of Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockadeJinteng Li, Ye, Feng, Xu, Xiaojun, Peitao Xu, Wang, Peng, Zheng, Guan, Guiwen Ye, Yu, Wenhui, Zepeng Su, Lin, Jiajie et al. · 2023 · Figshare
- Additional file 2 of Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockadeJinteng Li, Ye, Feng, Xu, Xiaojun, Peitao Xu, Wang, Peng, Zheng, Guan, Guiwen Ye, Yu, Wenhui, Zepeng Su, Lin, Jiajie et al. · 2023 · Figshare
- Additional file 8 of Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockadeJinteng Li, Ye, Feng, Xu, Xiaojun, Peitao Xu, Wang, Peng, Zheng, Guan, Guiwen Ye, Yu, Wenhui, Zepeng Su, Lin, Jiajie et al. · 2023 · Figshare
- Additional file 1 of Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockadeJinteng Li, Ye, Feng, Xu, Xiaojun, Peitao Xu, Wang, Peng, Zheng, Guan, Guiwen Ye, Wenhui Yu, Zepeng Su, Lin, Jiajie et al. · 2023 · Figshare
- Additional file 4 of Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockadeJinteng Li, Ye, Feng, Xu, Xiaojun, Peitao Xu, Wang, Peng, Zheng, Guan, Guiwen Ye, Yu, Wenhui, Zepeng Su, Lin, Jiajie et al. · 2023 · Figshare
- Additional file 3 of Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockadeJinteng Li, Ye, Feng, Xu, Xiaojun, Peitao Xu, Wang, Peng, Zheng, Guan, Guiwen Ye, Yu, Wenhui, Zepeng Su, Lin, Jiajie et al. · 2023 · Figshare
- Additional file 5 of Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockadeJinteng Li, Ye, Feng, Xu, Xiaojun, Peitao Xu, Wang, Peng, Zheng, Guan, Guiwen Ye, Yu, Wenhui, Zepeng Su, Lin, Jiajie et al. · 2023 · Figshare
- Additional file 9 of Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockadeJinteng Li, Ye, Feng, Xu, Xiaojun, Peitao Xu, Wang, Peng, Zheng, Guan, Guiwen Ye, Yu, Wenhui, Zepeng Su, Lin, Jiajie et al. · 2023 · Figshare
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- BindingDB Entry 50021924: Recent insights of PROTAC developments in inflammation-mediated and autoimmune targets: a critical review.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50018749: PROTAC: A promising technology for cancer treatment.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50019525: PROTACS: A technology with a gold rush-like atmosphere.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50007767: Small molecule PROTACs in targeted therapy: An emerging strategy to induce protein degradation.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50019232: Development of Human Carbonic Anhydrase II Heterobifunctional Degraders.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50018659: Developments of CRBN-based PROTACs as potential therapeutic agents.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50019825: Developments of PROTACs technology in immune-related diseases.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50006137: Proteases and Their Modulators in Cancer Therapy: Challenges and Opportunities.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50015475: Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50019142: Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50010598: Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50012315: Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC).BindingDB · 2022 · UC San Diego
- BindingDB Entry 50020612: Recent Advances on Small-Molecule Bromodomain-Containing Histone Acetyltransferase Inhibitors.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50006856: Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50023478: PROTAC unleashed: Unveiling the synthetic approaches and potential therapeutic applications.BindingDB · 2026 · UC San Diego
- BindingDB Entry 50018350: Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs).BindingDB · 2024 · UC San Diego
- BindingDB Entry 50007822: Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50020203: Exploitation of Proximity-Mediated Effects in Drug Discovery: An Update of Recent Research Highlights in Perturbing Pathogenic Proteins and Correlated Issues.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50021668: Technologies of targeting histone deacetylase in drug discovery: Current progress and emerging prospects.BindingDB · 2025 · UC San Diego