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Metabolism-based drug discovery in zebrafish: An emerging strategy to uncover new anti-seizure therapies

Ibhazehiebo, K., Rho, J. M., & Kurrasch, D. M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107988 · Cited by 15 · see citing works

Anti-seizure effects of medicinal plants in Malawi on pentylenetetrazole-induced seizures in zebrafish larvae

Gwedela, M. N. V., Terai, H., Lampiao, F., Matsunami, K., & Aizawa, H. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114763 · Cited by 14 · see citing works

Pharmacological modulation of autophagy for epilepsy therapy: Opportunities and obstacles

Chen, W., Zhang, J., Zhang, Y., Zhang, Y., Li, W., Sha, L., Xia, Y., & Chen, L. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103600 · Cited by 11 · see citing works

A theoretical and spectroscopic (NMR and IR) study of indirubin in solution and in the solid state

Alkorta, I., Elguero, J., Dardonville, C. Y., Reviriego, F., María, D. S., Claramunt, R. M., & Marín‐Luna, M. (2019) · Journal of Physical Organic Chemistry · doi:10.1002/poc.4043 · Cited by 9 · see citing works

Application of zebrafish ( Danio rerio ) as a model organism for central nervous system disorders screening of natural products

da Silva, A. W. R., Silva, L. K. D. F., Rambo, D. F., & Biegelmeyer, R. (2025) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgaf067 · Cited by 7 · see citing works

Targeting firing rate neuronal homeostasis can prevent seizures

Mulroe, F., Lin, W., Scott, C. M., Aourz, N., Fan, Y. N., Coutts, G., Parrish, R. R., Smolders, I. J., Trevelyan, A. J., Wykes, R. C., et al. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049703 · Cited by 7 · see citing works

Metformin Improves Spatial Memory and Reduces Seizure Severity in a Rat Model of Epilepsy and Alzheimer’s Disease comorbidity via PI3K/Akt Signaling Pathway

Alves, S. S., Rossi, L., de Oliveira, J. A. C., Servilha‐Menezes, G., Grigório-de-Sant’Ana, M., Mazzei, R. F., Almeida, S. S., Sebollela, A. S., da Silva-Júnior, R. M. P., & Garcia‐Cairasco, N. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04844-2 · Cited by 6 · see citing works

Difluorocarbene-Enabled Synthesis of 3-Substituted-2-oxoindoles from o-Vinylanilines

Huang, H., Li, X., Su, J., & Song, Q. (2023) · Chinese Journal of Organic Chemistry · doi:10.6023/cjoc202210031 · Cited by 5 · see citing works

Medium‐Chain Triglycerides Supplementation Protects Epilepsy‐Associated Behavioral Impairments in a Mouse Model

Kumar, A., Kumari, S., Dhiman, P., & Singh, D. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70213 · Cited by 3 · see citing works

Unraveling the Effects of GSK-3β Isoform Modulation against Limbic Seizures and in the 6 Hz Electrical Kindling Model for Epileptogenesis

Aourz, N., LEUVEN, F. V., Allaoui, W., Eeckhaut, A. V., Bundel, D. D., & Smolders, I. J. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00782 · Cited by 2 · see citing works

Identification of anti-epileptic natural products using zebrafish

Crawford, A. D. (2022) · Macedonian Pharmaceutical Bulletin · doi:10.33320/maced.pharm.bull.2022.68.04.081 · Cited by 2 · see citing works

Contrasting Effects of Inhibitors Li + and Be 2+ on Catalytic Cycle of Glycogen Synthase Kinase-3β

Reilley, D. J., Arraf, Z., & Alexandrova, A. N. (2021) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.1c05099 · Cited by 2 · see citing works

Seizures and epilepsy

da Silva, R. S., Vianna, M. R. M. R., & Bonan, C. D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817528-6.00024-3 · Cited by 2 · see citing works

Disrupting fzd9b in zebrafish recapitulates stress- and anxiety-like behaviours associated with Williams syndromePreprint

Torres-Pérez, J. V., Leggieri, A., Mech, A. M., Anagianni, S., Havelange, W., & Brennan, C. H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.22.576596 · Cited by 2 · see citing works

From comorbidity to continuum: Alzheimer’s disease and epilepsy are connected-now what?

Alves, S. S., Manzine, P. R., dos Santos, F. M., Migliaccio, M. M., Alves, L. D. C., da Silva-Júnior, R. M. P., Becerra-Hernández, L. V., González-Acosta, C. A., Buriticá, E., Cominetti, M. R., et al. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106682 · Cited by 1 · see citing works

Disrupting fzd9b in Zebrafish Recapitulates Stress- and Anxiety-Like Behaviours Relevant to Williams Syndrome

Torres-Pérez, J. V., Leggieri, A., Wang, X., Kehoe, A., Schalkwyk, L. V., Mech, A. M., Anagianni, S., Havelange, W., & Brennan, C. H. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06127-w · Cited by 1 · see citing works

Editors’ Favorites: Best of 2018

Lindsley, C. W., Abbott, C. M., Andrews, A. M., Hooker, J. M., & Zhou, J. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00717 · Cited by 1 · see citing works

Chemically-induced epileptic seizures in zebrafish: a systematic reviewPreprint

Chitolina, R., Gallas‐Lopes, M., Reis, C. G., Benvenutti, R., Stahlhofer-Buss, T., Calcagnotto, M. E., Herrmann, A. P., & Piato, Â. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.26.546569 · Cited by 1 · see citing works

Targeting neuronal homeostasis to prevent seizuresPreprint

Mulroe, F., Lin, W., Scott, C. M., Aourz, N., Fan, Y. N., Coutts, G., Parrish, R. R., Smolders, I. J., Trevelyan, A. J., Wykes, R. C., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.07.483229

NEW DRUGS FROM OLD MEDICINES: IDENTIFICATION OF ANTI-EPILEPTIC NATURAL PRODUCTS FROM MEDICINAL PLANTS

Crawford, A. D. (2023) · Journal of Research in Pharmacy · doi:10.29228/jrp.585

Deep learning enhanced deciphering of brain activity maps for discovery of therapeutics for brain disorders

Zhang, X., Liu, Z., Luo, X., Cao, Y. L., Zhang, W., Li, H., Li, W., Cheng, S. H., Haggarty, S. J., Wang, X., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112868

Multiomic Analyses Reveal Brainstem Metabolic Changes in a Mouse Model of Dravet Syndrome

Hari, A. S., Chan, A. M., Scholl, A., Mulligan, A. J., Camacho, J., Kearns, I. R., Vasquez-Opazo, G. A., Cheminant, J. R., Musci, T. S., Goh, M.-J., et al. (2025) · Cells · doi:10.3390/cells15010067

Selective disruption of tau–SH3 interactions rescues seizure and sleep phenotypes

Shandilya, M., Koutures, A., Addo-Osafo, K., Hwang, K., Vicente, M. C., Ewens, A. N., Katz, B. M., Peters, S., Choquette, J. M., Vaknalli, R. N., et al. (2026) · Brain · doi:10.1093/brain/awag090

High-frequency oscillations arise through distinct mechanisms in models of α- synucleinopathy and channelopathy-induced epilepsyPreprint

Vaknalli, R. N., Addo-Osafo, K., Chenchu, V. S. M., Hwang, K., de Vicente, M., Bragin, A., & Vossel, K. A. (2026) · Research Square · doi:10.21203/rs.3.rs-10385398/v1

Abnormal KCC2 expression and function in a mouse model of epilepsy and tuberous sclerosis complex

Guo, D., Han, L., Rensing, N. R., Jansen, L. A., & Wong, M. L. (2026) · Epilepsia · doi:10.1002/epi.70434

BindingDB Entry 50013135: Structure-Based Design of Potent Selective Nanomolar Type-II Inhibitors of Glycogen Synthase Kinase-3β.

BindingDB (2022) · UC San Diego · doi:10.7270/q2mk6hmm

Zebrafish Bioassay-Guided Microfractionation Identifies Anticonvulsant Steroid Glycosides from the Philippine Medicinal PlantSolanum torvum

Challal, S., Buenafe, O. E. M., Queiroz, E. F., Maljevic, S., Marcourt, L., Bock, M., Kloeti, W., Dayrit, F. M., Harvey, A. L., Lerche, H., et al. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn5001342 · Cited by 62 · see citing works

Elucidating the role of Glygocen synthase kinase-3 in epilepsy.

Aourz, N., Walrave, L., Camila, E., Peter, D. W., Fred, V. L., Alexander, C., & Smolders, I. J. (2015) · Frontiers in Neuroscience · doi:10.3389/conf.fnins.2015.89.00034

Unraveling the Effects of GSK-3β Isoform Modulation against Limbic Seizures and in the 6 Hz Electrical Kindling Model for Epileptogenesis

Aourz, N., LEUVEN, F. V., Allaoui, W., Eeckhaut, A. V., Bundel, D. D., & Smolders, I. J. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00782 · Cited by 2 · see citing works

NEW DRUGS FROM OLD MEDICINES: IDENTIFICATION OF ANTI-EPILEPTIC NATURAL PRODUCTS FROM MEDICINAL PLANTS

Crawford, A. D. (2023) · Journal of Research in Pharmacy · doi:10.29228/jrp.585

Medicinal Plants to Treat Epilepsy: Discovery of Antiseizure Compounds by In Vivo Zebrafish Bioactivity-Guided Isolation

Brillatz, T. (2020) · Archive ouverte UNIGE (University of Geneva) · doi:10.13097/archive-ouverte/unige:138129