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Emerging Trends in Polymerization-Induced Self-Assembly

Open access
Penfold, Nicholas J. W., Yeow, Jonathan, Boyer, Cyrille, Armes, Steven P.·2019·ACS Macro Letters

Abstract

In this Perspective, we summarize recent progress in polymerization-induced self-assembly (PISA) for the rational synthesis of block copolymer nanoparticles with various morphologies. Much of the PISA literature has been based on thermally initiated reversible addition-fragmentation chain transfer (RAFT) polymerization. Herein, we pay particular attention to alternative PISA protocols, which allow the preparation of nanoparticles with improved control over copolymer morphology and functionality. For example, initiation based on visible light, redox chemistry, or enzymes enables the incorporation of sensitive monomers and fragile biomolecules into block copolymer nanoparticles. Furthermore, PISA syntheses and postfunctionalization of the resulting nanoparticles (e.g., cross-linking) can be conducted sequentially without intermediate purification by using various external stimuli. Finally, PISA formulations have been optimized via high-throughput polymerization and recently evaluated within flow reactors for facile scale-up syntheses.

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Crossref · 10.1021/acsmacrolett.9b00464

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Metadata

Authors
Penfold, N. J. W., Yeow, J., Boyer, C., & Armes, S. P.
Venue
ACS Macro Letters
Published
2019-08-07
Volume
8
Issue
8
Pages
1029-1054
ISSN
2161-1653 (ISSN-L)
OpenAlex
W2965497785
Cited by
647
References
2
FWCI
29.96
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Emerging Trends in Polymerization-Induced Self-Assembly. https://app.cochat.ai/papers/10.1021/acsmacrolett.9b00464
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Penfold, N. J. W., Yeow, J., Boyer, C., & Armes, S. P. (2019). Emerging Trends in Polymerization-Induced Self-Assembly. ACS Macro Letters. https://doi.org/10.1021/acsmacrolett.9b00464

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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