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Hollow Magnetic Nanocatalysts Drive Starvation–Chemodynamic–Hyperthermia Synergistic Therapy for Tumor
Abstract
Magnetic hyperthermia therapy (MHT) has been considered as an excellent alternative for treatment of deep tumor tissue; however, up-regulation of heat shock proteins (HSPs) impairs its hyperthermal therapeutic effect. Reactive oxygen species (ROS) and competitive consumption of ATP are important targets that can block excessive HSP generation. We developed a magnetic nanocatalytic system comprised of glucose oxidase (GOD)-loaded hollow iron oxide nanocatalysts (HIONCs) to drive starvation–chemodynamic–hyperthermia synergistic therapy for tumor treatment. The Fe 2+ present in HIONCs contributed to ROS generation via the Fenton reaction, relieving thermo-resistance and inducing cell apoptosis by chemodynamic action. The Fenton effect was enhanced through the conditions created by increased MHT-related temperature, GOD-mediated H 2 O 2 accumulation, and elevated tumor microenvironment acidity. The HIONCs catalase-like activity facilitated conversion of H 2 O 2 to oxygen, thereby replenishing the oxygen levels. We further demonstrated that locally injected HIONCs-GOD effectively inhibited tumor growth in PC3 tumor-bearing mice. This study presents a multifunctional nanocarrier system driving starvation–chemodynamic–magnetic–thermal synergistic therapy via ROS and oxygen modulation for prostate tumor treatment.
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Cites
Hydrogen peroxide in the human body
Halliwell, B., Clement, M. V., & Long, L. H. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02197-9 · Cited by 1,075
Cited by
Zhou, Y., Fan, S., Feng, L., Huang, X., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202104223 · Cited by 463
Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry
Cao, C., Wang, X., Yang, N., Song, X., & Dong, X. (2022) · Chemical Science · doi:10.1039/d1sc05482a · Cited by 298
Strategies for enhancing cancer chemodynamic therapy performance
Jana, D., & Zhao, Y. (2022) · Exploration · doi:10.1002/exp.20210238 · Cited by 284
Dong, S., Dong, Y., Zhao, Z., Liu, J., Liu, S., Feng, L., He, F., Gai, S., Xie, Y., & Yang, P. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c09608 · Cited by 267
Metadata
- Authors
- Ying, W., Zhang, Y., Gao, W., Cai, X., Wang, G., Wu, X., Chen, L., Meng, Z., Zheng, Y., Hu, B., & Lin, X.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-07-24
- Volume
- 14
- Issue
- 8
- Pages
- 9662-9674
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W3044116725
- Cited by
- 169
- References
- 1
- FWCI
- 7.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ying, W., Zhang, Y., Gao, W., Cai, X., Wang, G., Wu, X., Chen, L., Meng, Z., Zheng, Y., Hu, B., & Lin, X. (2020). Hollow Magnetic Nanocatalysts Drive Starvation–Chemodynamic–Hyperthermia Synergistic Therapy for Tumor. ACS Nano. https://doi.org/10.1021/acsnano.0c00910
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