The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Elucidating the Fundamental Mechanisms of Cell Death Triggered by Photothermal Therapy
Abstract
Photothermal therapy (PTT) utilizes nanoparticles embedded within tumors as exogenous energy absorbers to convert laser light energy into heat to ablate cancer cells. While PTT is a promising alternative to conventional cancer therapy, under certain irradiation conditions, it can produce cellular necrosis, and this necrosis may lead to pro-inflammatory responses that are detrimental to treatment success. Recent studies have shown that PTT can be modulated to induce apoptosis rather than necrosis, which is appealing since apoptosis discourages an inflammatory response. In this issue of ACS Nano, del Pino, Pardo, de la Fuente, and colleagues reveal the intracellular signaling cascades involved in the apoptotic response to PTT using cells harboring photothermal transducing nanoprisms. In this Perspective, we present an overview of nanoparticle-mediated PTT and discuss photothermally induced apoptosis as a potential therapeutic pathway.
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Cites
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Dissecting the Molecular Mechanism of Apoptosis during Photothermal Therapy Using Gold Nanoprisms
Pérez-Hernández, M., del Pino, P., Mitchell, S. G., Moros, M., Stepien, G., Pelaz, B., Parak, W. J., Gálvez, E. M., Pardo, J., & de la Fuente, J. M. (2015) · ACS Nano · doi:10.1021/nn505468v · Cited by 398
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Cited by
Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles
Abadeer, N. S., & Murphy, C. J. (2016) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.5b11232 · Cited by 919
Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications
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Nanoagent‐Promoted Mild‐Temperature Photothermal Therapy for Cancer Treatment
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Metadata
- Authors
- Melamed, J. R., Edelstein, R. S., & Day, E. S.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-01-15
- Volume
- 9
- Issue
- 1
- Pages
- 6-11
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2312941501
- Cited by
- 657
- References
- 15
- FWCI
- 17.30
- Type
- journal article
- Language
- en
- Open access
- closed
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