The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Dissecting the Molecular Mechanism of Apoptosis during Photothermal Therapy Using Gold Nanoprisms
Open accessAbstract
The photothermal response of plasmonic nanomaterials can be exploited for a number of biomedical applications in diagnostics (biosensing and optoacoustic imaging) and therapy (drug delivery and photothermal therapy). The most common cellular response to photothermal cancer treatment (ablation of solid tumors) using plasmonic nanomaterials is necrosis, a process that releases intracellular constituents into the extracellular milieu producing detrimental inflammatory responses. Here we report the use of laser-induced photothermal therapy employing gold nanoprisms (NPRs) to specifically induce apoptosis in mouse embryonic fibroblast cells transformed with the SV40 virus. Laser-irradiated "hot" NPRs activate the intrinsic/mitochondrial pathway of apoptosis (programmed cell death), which is mediated by the nuclear-encoded proteins Bak and Bax through the activation of the BH3-only protein Bid. We confirm that an apoptosis mechanism is responsible by showing how the NPR-mediated cell death is dependent on the presence of caspase-9 and caspase-3 proteins. The ability to selectively induce apoptotic cell death and to understand the subsequent mechanisms provides the foundations to predict and optimize NP-based photothermal therapy to treat cancer patients suffering from chemo- and radioresistance.
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Cites
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Self-citationExploring treatment options in cancer: tumor treatment strategies
Liu, B., Zhou, H., Tan, L., Siu, K. T. H., & Guan, X.-Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01856-7 · Cited by 1,201
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In vivo degeneration and the fate of inorganic nanoparticles
Feliu, N., Docter, D., Heine, M., del Pino, P., Ashraf, S., Kolosnjaj-Tabi, J., Macchiarini, P., Nielsen, P., Alloyeau, D., Gazeau, F., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00699f · Cited by 423
Self-citationCai, W., Gao, H., Chu, C., Wang, X., Wang, J., Zhang, P., Lin, G., Li, W., Liu, G., & Chen, X. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b11579 · Cited by 357
Metadata
- Authors
- Pérez-Hernández, M., del Pino, P., Mitchell, S. G., Moros, M., Stepien, G., Pelaz, B., Parak, W. J., Gálvez, E. M., Pardo, J., & de la Fuente, J. M.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-12-17
- Volume
- 9
- Issue
- 1
- Pages
- 52-61
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2064753738
- Cited by
- 398
- References
- 55
- FWCI
- 14.07
- Type
- journal article
- Language
- en
- Open access
- green
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