Microfluidics Enabled Bottom-Up Engineering of 3D Vascularized Tumor for Drug Discovery

Agarwal, Pranay, Wang, Hai, Sun, Mingrui, Xu, Jiangsheng, Zhao, Shuting, Liu, Zhenguo, Gooch, Keith J., Zhao, Yi +2 more·2017·ACS Nano

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  5. Solventless preparation of ammonium persulfate microcapsules with a polypyrrole shell
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  8. Realizations of vascularized tissues: From in vitro platforms to in vivo grafts
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  13. Advancing Point-of-Care Applications with Droplet Microfluidics: From Single-Cell to Multicellular Analysis
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  14. Rapid Fabrication of Diverse Hydrogel Microspheres for Drug Evaluation on a Rotating Microfluidic System
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  16. Revolutionizing drug evaluation system with organ-on-a-chip and artificial intelligence: A critical review
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  17. Three-Dimensional Culture Models: Emerging Platforms for Screening The Antitumoral Efficacy of Nanomedicines
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  18. Microfluidic Particle Reactors: From Interface Characteristics to Cells and Drugs Related Biomedical Applications
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  19. An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models
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  20. Matrix-integrated microfluidic tumor models for evaluating drug delivery systems and pre-clinical testing
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  21. Image entropy-based label-free functional characterization of human induced pluripotent stem cell-derived 3D cardiac spheroids
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  22. Exploring the Design Efficiency of Random Microfluidic Mixers
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  31. Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development
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  32. Engineering vascularized organotypic tissues via module assembly
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  35. Organ-on-Chip Devices Toward Applications in Drug Development and Screening
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  37. Customizable biomaterials as tools for advanced anti-angiogenic drug discovery
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  51. Modular formation of in vitro tumor models for oncological research/therapeutic drug screening
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  52. Sticker microfluidics: A toolbox of combinable sacrificial templates for instrument-free customization of complex microfluidic systems in one-piece
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  53. Droplet microfluidics for biomedical devices
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  54. Research Progress of Fabrication and Applications in Microfluidic Devices
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  58. Shedding lights on cancer cells and their microenvironment : development of 3D in vitro tumor models to shorten the translation of nanomedicines from the bench to the bedside
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  61. Towards ultrasensitive SERS: Site-specific analyte enrichment achieved by laser-controlled droplet evaporation on superhydrophobic/-philic surfaces
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  62. VitroOrganoSphere (VOS): an automated droplet-engineered organoid sorting platform
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  63. Tumor Microenvironment-on-a-Chip: Construction and Application in Traditional Chinese Medicine Anti-Tumor Therapy
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  65. Functional Vascularization in Tumor Organoid and Tumor-on-Chip Models: Evidence Requirements for Attributing Therapy-Resistance Mechanisms
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  66. Tissue Fabrication Technology: Vascularization and Innervation
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