Biomacromolecular hydrogel scaffolds from microfluidics for cancer therapy: A review
Abstract
Traditional cancer treatment is confronted with the problem of limited therapeutic effect, tissue defects, and lack of drug screening. Hydrogel scaffolds from biological macromolecules based on microfluidic technology are a promising candidate, which can mimic tumor microenvironments to screen personalized drugs, promote the regeneration of healthy tissues, and deliver drugs for enhanced localized antitumor treatment. This review summarizes the latest research on the composition of biomacromolecular hydrogel scaffolds, the architecture of hydrogel scaffolds from microfluidic technology, and their application in cancer therapy, including anti-tumor drug screening, anti-tumor treatment, and anti-tumor treatment and tissue repair. In addition, the potential breakthroughs of this innovative platform in the clinical transformation of cancer therapy are further discussed. The insights revealed in this review are intended to guide the utilization of microfluidic technology-based biomacromolecular hydrogel scaffolds in cancer therapy.
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PLCL can be fabricated into three-dimensional scaffolds with high porosity and specific surface area via electrospinning and suspended microsphere fabrication, greatly simulating structure and morphology of extracellular matrix and realizing purpose of drug screening.
“Owing to its excellent processability, PLCL can be fabricated into three-dimensional scaffolds with high porosity and specific surface area via techniques such as electrospinning and suspended microsphere fabrication, which can greatly simulate the structure and morphology of extracellular matrix and realize the purpose of drug screening [218].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [218]
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Application of PLCL as a biodegradable polymer in biomedical engineering
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- Authors
- Hao, S., Shi, L., Li, J., Shi, J., Kuang, G., Liang, G., & Gao, S.
- Affiliations
- Henan University of Science and Technology (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Corresponding author
- Shi, Linlin
- Kuang, Gaizhen
- Liang, Gaofeng
- Gao, Shegan
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2024-12
- Volume
- 282
- Issue
- Pt 1
- Pages
- 136738
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W4403570927
- Cited by
- 7
- References
- 161
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 1
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82302966, 32201118)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Keywords
- cancer therapy, personalized drug screening, anticancer drug delivery, tissue regeneration, tissue repair, clinical translation
- MeSH terms
- Animals, Antineoplastic Agents, Humans, Neoplasms, Drug Delivery Systems, Hydrogels, Microfluidics, Tissue Scaffolds, Tumor Microenvironment
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