Cited by 7Hydrogels: synthesis, properties, applications3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Biomacromolecular hydrogel scaffolds from microfluidics for cancer therapy: A review

Hao, Siyu, Shi, Linlin, Li, Jiayi, Shi, Jiaming, Kuang, Gaizhen, Liang, Gaofeng, Gao, Shegan·2024·International Journal of Biological Macromolecules

Abstract

Traditional cancer treatment is confronted with the problem of limited therapeutic effect, tissue defects, and lack of drug screening. Hydrogel scaffolds from biological macromolecules based on microfluidic technology are a promising candidate, which can mimic tumor microenvironments to screen personalized drugs, promote the regeneration of healthy tissues, and deliver drugs for enhanced localized antitumor treatment. This review summarizes the latest research on the composition of biomacromolecular hydrogel scaffolds, the architecture of hydrogel scaffolds from microfluidic technology, and their application in cancer therapy, including anti-tumor drug screening, anti-tumor treatment, and anti-tumor treatment and tissue repair. In addition, the potential breakthroughs of this innovative platform in the clinical transformation of cancer therapy are further discussed. The insights revealed in this review are intended to guide the utilization of microfluidic technology-based biomacromolecular hydrogel scaffolds in cancer therapy.

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Crossref · 10.1016/j.ijbiomac.2024.136738

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161 of 161 references verified0 citation errors · 0 not checkable

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  • PLCL can be fabricated into three-dimensional scaffolds with high porosity and specific surface area via electrospinning and suspended microsphere fabrication, greatly simulating structure and morphology of extracellular matrix and realizing purpose of drug screening.

    “Owing to its excellent processability, PLCL can be fabricated into three-dimensional scaffolds with high porosity and specific surface area via techniques such as electrospinning and suspended microsphere fabrication, which can greatly simulate the structure and morphology of extracellular matrix and realize the purpose of drug screening [218].”

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Authors
Hao, S., Shi, L., Li, J., Shi, J., Kuang, G., Liang, G., & Gao, S.
Affiliations
  • Henan University of Science and Technology (CN)
  • First Affiliated Hospital of Wenzhou Medical University (CN)
Corresponding author
  • Shi, Linlin
  • Kuang, Gaizhen
  • Liang, Gaofeng
  • Gao, Shegan
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2024-12
Volume
282
Issue
Pt 1
Pages
136738
ISSN
0141-8130 (ISSN-L)
OpenAlex
W4403570927
Cited by
7
References
161
Citations by year
2026: 5 · 2025: 1 · 2024: 1
FWCI
0.20
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Biological Macromolecules (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (82302966, 32201118)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
Keywords
cancer therapy, personalized drug screening, anticancer drug delivery, tissue regeneration, tissue repair, clinical translation
MeSH terms
Animals, Antineoplastic Agents, Humans, Neoplasms, Drug Delivery Systems, Hydrogels, Microfluidics, Tissue Scaffolds, Tumor Microenvironment

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