The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Pharmaceutical Intermediate-Modified Gold Nanoparticles: Against Multidrug-Resistant Bacteria and Wound-Healing Application via an Electrospun Scaffold
Abstract
Remedying a multidrug-resistant (MDR) bacteria wound infection is a major challenge due to the inability of conventional antibiotics to treat such infections against MDR bacteria. Thus, developing wound dressings for wound care, particularly against MDR bacteria, is in huge demand. Here, we present a strategy in designing wound dressings: we use a small molecule (6-aminopenicillanic acid, APA)-coated gold nanoparticles (AuNPs) to inhibit MDR bacteria. We dope the AuNPs into electrospun fibers of poly(ε-caprolactone) (PCL)/gelatin to yield materials that guard against wound infection by MDR bacteria. We systematically evaluate the bactericidal activity of the AuNPs and wound-healing capability via the electrospun scaffold. APA-modified AuNPs (Au_APA) exhibit remarkable antibacterial activity even when confronted with MDR bacteria. Meanwhile, Au_APA has outstanding biocompatibility. Moreover, an in vivo bacteria-infected wound-healing experiment indicates that it has a striking ability to remedy a MDR bacteria wound infection. This wound scaffold can assist the wound care for bacterial infections.
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Cites
Kittler, S., Greulich, C., Diendorf, J., Köller, M., & Epple, M. (2010) · Chemistry of Materials · doi:10.1021/cm100023p · Cited by 1,126
Albers, S.-V., & Meyer, B. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2576 · Cited by 542
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Wang, S., Zheng, H., Zhou, L., Cheng, F., Liu, Z., Zhang, H., Wang, L., & Zhang, Q. (2020) · Nano Letters · doi:10.1021/acs.nanolett.0c01371 · Cited by 573
Self-citationBioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing
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Metadata
- Authors
- Yang, X., Yang, J., Wang, L., Ran, B., Jia, Y., Zhang, L., Yang, G., Shao, H., & Jiang, X.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-05-25
- Volume
- 11
- Issue
- 6
- Pages
- 5737-5745
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2618245525
- Cited by
- 376
- References
- 2
- FWCI
- 31.42
- Type
- journal article
- Language
- en
- Open access
- closed
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