The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Nanoenzyme-Reinforced Injectable Hydrogel for Healing Diabetic Wounds Infected with Multidrug Resistant Bacteria
Abstract
Diabetic wound healing remains a critical challenge due to its vulnerability to multidrug-resistant (MDR) bacterial infection, as well as the hyperglycemic and oxidative wound microenvironment. Herein, an injectable multifunctional hydrogel (FEMI) was developed to simultaneously overcome these hurdles. The FEMI hydrogel was fabricated through a Schiff-based reaction between ε-polylysine (EPL)-coated MnO 2 nanosheets (EM) and insulin-loaded self-assembled aldehyde Pluronic F127 (FCHO) micelles. Through a synergistic combination of EPL and “nanoknife-like” MnO 2 nanosheets, the FEMI hydrogel exhibited extraordinary antimicrobial capacities against MDR bacteria. The MnO 2 nanoenzyme reshaped the hostile oxidative wound microenvironment by decomposing the endogenous H 2 O 2 into O 2 . Meanwhile, the pH/redox dual-responsive FEMI hydrogel achieved a sustained and spatiotemporal controlled release of insulin to regulate the blood glucose. Our FEMI hydrogel demonstrated an accelerated MDR bacteria-infected diabetic wound healing in vivo and represents a versatile strategy for healing a broad range of tissue damages caused by diabetes.
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Cites
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562
Advances in engineering hydrogels
Zhang, Y. S., & Khademhosseini, A. (2017) · Science · doi:10.1126/science.aaf3627 · Cited by 2,908
Wound healing and its impairment in the diabetic foot
Falanga, V. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67700-8 · Cited by 2,639
Qu, J., Zhao, X., Liang, Y., Zhang, T., Ma, P. X., & Guo, B. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.044 · Cited by 1,809
Diabetes primes neutrophils to undergo NETosis, which impairs wound healing
Wong, S. L., Demers, M., Martinod, K., Gallant, M., Wang, Y., Goldfine, A. B., Kahn, C. R., & Wagner, D. D. (2015) · Nature Medicine · doi:10.1038/nm.3887 · Cited by 1,264
Zhao, X., Guo, B., Wu, H., Liang, Y., & Ma, P. X. (2018) · Nature Communications · doi:10.1038/s41467-018-04998-9 · Cited by 1,161
Griffin, D. R., Weaver, W. M., Scumpia, P. O., Di Carlo, D., & Segura, T. (2015) · Nature Materials · doi:10.1038/nmat4294 · Cited by 981
Advances in skin grafting and treatment of cutaneous wounds
Sun, B. K., Siprashvili, Z., & Khavari, P. A. (2014) · Science · doi:10.1126/science.1253836 · Cited by 972
In situ forming injectable hydrogels for drug delivery and wound repair
Dimatteo, R., Darling, N. J., & Segura, T. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.03.007 · Cited by 896
Cited by
Haemostatic materials for wound healing applications
Guo, B., Dong, R., Liang, Y., & Li, M. (2021) · Nature Reviews Chemistry · doi:10.1038/s41570-021-00323-z · Cited by 992
Self-Healing Injectable Hydrogels for Tissue Regeneration
Bertsch, P., Diba, M., Mooney, D. J., & Leeuwenburgh, S. C. G. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00179 · Cited by 892
Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine
Huang, F., Lu, X., Yang, Y., Yang, Y., Li, Y., Kuai, L., Li, B., Dong, H., & Shi, J. (2023) · Advanced Science · doi:10.1002/advs.202203308 · Cited by 365
Xiong, Y., Chen, L., Liu, P., Yu, T., Lin, C., Yan, C., Hu, Y., Zhou, W., Sun, Y., Panayi, A. C., et al. (2022) · Small · doi:10.1002/smll.202104229 · Cited by 331
Cheng, T., Zhang, Y., Wang, S., Chen, Y., Gao, S., Wang, F., Lai, W., & Huang, W. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202101303 · Cited by 308
Self-citation
Metadata
- Authors
- Wang, S., Zheng, H., Zhou, L., Cheng, F., Liu, Z., Zhang, H., Wang, L., & Zhang, Q.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-06-23
- Volume
- 20
- Issue
- 7
- Pages
- 5149-5158
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W3037181905
- Cited by
- 573
- References
- 56
- FWCI
- 37.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, S., Zheng, H., Zhou, L., Cheng, F., Liu, Z., Zhang, H., Wang, L., & Zhang, Q. (2020). Nanoenzyme-Reinforced Injectable Hydrogel for Healing Diabetic Wounds Infected with Multidrug Resistant Bacteria. Nano Letters. https://doi.org/10.1021/acs.nanolett.0c01371
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