The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Biodegradable Hollow Mesoporous Organosilica Nanotheranostics for Mild Hyperthermia-Induced Bubble-Enhanced Oxygen-Sensitized Radiotherapy
Abstract
Alleviation of tumor hypoxia has been the premise for improving the effectiveness of radiotherapy, which hinges upon the advanced delivery and rapid release of oxygen within the tumor region. Herein, we propose a “bubble-enhanced oxygen diffusion” strategy to achieve whole tumor oxygenation for significant radiation enhancement based on the “bystander effect”. Toward this end, sub-50 nm CuS-modified and 64 Cu-labeled hollow mesoporous organosilica nanoparticles were constructed for tumor-specific delivery of O 2 -saturated perfluoropentane (PFP). Through the aid of PFP gasification arising from NIR laser-triggered mild hyperthermia, simultaneous PET/PA/US multimodality imaging and rapid oxygen diffusion across the tumor can be achieved for remarkable hypoxic radiosensitization. Furthermore, the multifunctional oxygen-carrying nanotheranostics also allow for other oxygen-dependent treatments, thus greatly advancing the development of bubble-enhanced synergistic therapy platforms.
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Cites
Exploiting tumour hypoxia in cancer treatment
Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828
Cheng, Y., Cheng, H., Jiang, C., Qiu, X., Wang, K., Huan, W., Yuan, A., Wu, J., & Hu, Y. (2015) · Nature Communications · doi:10.1038/ncomms9785 · Cited by 941
Cited by
Inorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
Zhang, C., Yan, K., Fu, C., Peng, H., Hawker, C. J., & Whittaker, A. K. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00632 · Cited by 493
Feng, L., Xie, R., Wang, C., Gai, S., He, F., Yang, D., Yang, P., & Lin, J. (2018) · ACS Nano · doi:10.1021/acsnano.8b05042 · Cited by 422
X-ray-activated nanosystems for theranostic applications
Chen, X., Song, J., Chen, X., & Yang, H. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00921j · Cited by 401
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Metadata
- Authors
- Lu, N., Fan, W., Yi, X., Wang, S., Wang, Z., Tian, R., Jacobson, O., Liu, Y., Yung, B. C., Zhang, G., Teng, Z., Yang, K., Zhang, M., Niu, G., Lu, G., & Chen, X.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-02-05
- Volume
- 12
- Issue
- 2
- Pages
- 1580-1591
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2787524634
- Cited by
- 198
- References
- 2
- FWCI
- 11.23
- Type
- journal article
- Language
- en
- Open access
- closed
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