Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy
Open accessAbstract
Photodynamic therapy (PDT) kills cancer cells by converting tumour oxygen into reactive singlet oxygen ( 1 O 2 ) using a photosensitizer. However, pre-existing hypoxia in tumours and oxygen consumption during PDT can result in an inadequate oxygen supply, which in turn hampers photodynamic efficacy. Here to overcome this problem, we create oxygen self-enriching photodynamic therapy (Oxy-PDT) by loading a photosensitizer into perfluorocarbon nanodroplets. Because of the higher oxygen capacity and longer 1 O 2 lifetime of perfluorocarbon, the photodynamic effect of the loaded photosensitizer is significantly enhanced, as demonstrated by the accelerated generation of 1 O 2 and elevated cytotoxicity. Following direct injection into tumours, in vivo studies reveal tumour growth inhibition in the Oxy-PDT-treated mice. In addition, a single-dose intravenous injection of Oxy-PDT into tumour-bearing mice significantly inhibits tumour growth, whereas traditional PDT has no effect. Oxy-PDT may enable the enhancement of existing clinical PDT and future PDT design.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The tumor growth inhibition effect of PDT was promoted by loading photosensitizer and O2 into perfluorocarbon nanodroplets.
“The tumor growth inhibition effect of PDT was promoted by loading photosensitizer and O2 into perfluorocarbon nanodroplets. 447”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [447]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Photodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145 · see citing works
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233 · see citing works
Factors affecting the clearance and biodistribution of polymeric nanoparticles
Alexis, F., Pridgen, E., Molnar, L. K., & Farokhzad, O. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800051m · Cited by 3,699 · see citing works
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
Hockel, M., & Vaupel, P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.266 · Cited by 2,662 · see citing works
HOW DOES PHOTODYNAMIC THERAPY WORK?
Henderson, B. W., & Dougherty, T. J. (1992) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1992.tb04222.x · Cited by 2,376 · see citing works
Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization
Celli, J. P., Spring, B. Q., Rizvi, I., Evans, C. L., Samkoe, K. S., Verma, S., Pogue, B. W., & Hasan, T. G. (2010) · Chemical Reviews · doi:10.1021/cr900300p · Cited by 2,334 · see citing works
Hyperbaric Oxygen: Its Mechanisms and Efficacy
Thom, S. R. (2011) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e3181fbe2bf · Cited by 591 · see citing works
Tracking immune cells in vivo using magnetic resonance imaging
Ahrens, E. T., & Bulte, J. W. M. (2013) · Nature reviews. Immunology · doi:10.1038/nri3531 · Cited by 492 · see citing works
Relationship of tumor hypoxia and response to photodynamic treatment in an experimental mouse tumor.
Henderson, B. W., & Fingar, V. H. (1987) · PubMed · Cited by 339 · see citing works
Perfluorocarbon‐Based Oxygen Carriers: Review of Products and Trials
Castro, C. I., & Briceño, J. C. (2010) · Artificial Organs · doi:10.1111/j.1525-1594.2009.00944.x · Cited by 334 · see citing works
Sitnik, T., Hampton, J., & Henderson, B. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.231 · Cited by 260 · see citing works
Photodynamic therapy induced vascular damage: an overview of experimental PDT
Wang, W., Moriyama, L. T., & Bagnato, V. S. (2012) · Laser Physics Letters · doi:10.1088/1612-2011/10/2/023001 · Cited by 187 · see citing works
Zhou, Y., Wang, Z., Chen, Y., Shen, H., Luo, Z., Li, A., Wang, Q., Ran, H., Li, P., Song, W., et al. (2013) · Advanced Materials · doi:10.1002/adma.201301655 · Cited by 184 · see citing works
The Role of Oxygen in Cutaneous Photodynamic Therapy
Fuchs, J., & Thiele, J. J. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00370-5 · Cited by 178 · see citing works
Labeling cells for in vivo tracking using 19F MRI
Srinivas, M., Boehm‐Sturm, P., Figdor, C. G., de Vries, I. J., & Hoehn, M. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.08.048 · Cited by 145 · see citing works
Biophysical Aspects of Photodynamic Therapy
Juzeniene, A., Nielsen, K. P., & Moan, J. E. (2006) · Journal of Environmental Pathology Toxicology and Oncology · doi:10.1615/jenvironpatholtoxicoloncol.v25.i1-2.20 · Cited by 123 · see citing works
Tumor Vascular Microenvironment Determines Responsiveness to Photodynamic Therapy
Maas, A. L., Carter, S. L., Wileyto, E. P., Miller, J. M., Yuan, M., Yu, G., Durham, A. C., & Busch, T. M. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3744 · Cited by 104 · see citing works
Curnow, A., Mcllroy, B. W., Postle‐Hacon, M. J., MacRobert, A. J., & Bown, S. G. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb05308.x · Cited by 84 · see citing works
Maier, A., Anegg, U., Fell, B., Rehak, P., Ratzenhofer, B., Tomaselli, F., Sankin, O., Pinter, H., Smolle-J�ttner, F. M., & Friehs, G. B. (2000) · Lasers in Surgery and Medicine · doi:10.1002/(sici)1096-9101(2000)26:3 · Cited by 77 · see citing works
Fingar, V. H., Mang, T., & Henderson, B. W. (1988) · PubMed · Cited by 63 · see citing works
Hyperbaric oxygen and photodynamic therapy in tumour-bearing nude mice
Jirsa, M., POUCKOVA, P., Doležal, J., Pospíšil, J., & Jirsa, M. (1991) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(91)90075-o · Cited by 44 · see citing works
Tomaselli, F. (2001) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(01)00635-2 · Cited by 37 · see citing works
Maier, A., Anegg, U., Tomaselli, F., Rehak, P., Sankin, O., Fell, B., Renner, H., Pinter, H., Smolle-Jüttner, F.-M., & Friehs, G. B. (2002) · Endoscopy · doi:10.1055/s-2000-132 · Cited by 36 · see citing works
Busch, T. M., Wang, H.-W., Wileyto, E. P., Yu, G., & Bunte, R. M. (2010) · Radiation Research · doi:10.1667/rr2075.1 · Cited by 33 · see citing works
Gc, D., Sx, H., Gy, Z., Gao, S. Z., & Lr, W. (1987) · PubMed · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
Zhou, Z., Song, J., Nie, L., & Chen, X. S. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00271d · Cited by 2,104 · see citing works
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813 · see citing works
Innovative Strategies for Hypoxic‐Tumor Photodynamic Therapy
Li, X., Kwon, N., Guo, T., Liu, Z., & Yoon, J. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201805138 · Cited by 1,176 · see citing works
Li, W., Yang, J., Luo, L., Jiang, M., Qin, B., Yin, H., Zhu, C., Yuan, X., Zhang, J., Luo, Z., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11269-8 · Cited by 1,129 · see citing works
Dai, Y., Xu, C., Sun, X., & Chen, X. S. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00592f · Cited by 931 · see citing works
Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications
Hu, F., Xu, S., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201801350 · Cited by 859 · see citing works
Nanozyme Decorated Metal–Organic Frameworks for Enhanced Photodynamic Therapy
Zhang, Y., Wang, F., Liu, C., Wang, Z., Kang, L., Huang, Y., Dong, K., Ren, J., & Qu, X. (2018) · ACS Nano · doi:10.1021/acsnano.7b07746 · Cited by 854 · see citing works
Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia
Liu, J., Bu, W., & Shi, J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00525 · Cited by 840 · see citing works
Kim, J., Cho, H. R., Jeon, H., Kim, D., Song, C., Lee, N., Choi, S. H., & Hyeon, T. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b05559 · Cited by 709 · see citing works
Conquering the Hypoxia Limitation for Photodynamic Therapy
Wan, Y., Fu, L., Li, C., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202103978 · Cited by 705 · see citing works
Li, M., Xia, J., Tian, R., Wang, J., Fan, J., Du, J., Long, S., Song, X., Foley, J. W., & Peng, X. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b08658 · Cited by 676 · see citing works
Zheng, D., Li, B., Li, C., Fan, J., Lei, Q., Li, C., Xu, Z., & Zhang, X. (2016) · ACS Nano · doi:10.1021/acsnano.6b04156 · Cited by 665 · see citing works
Wang, Z., Zhang, Y., Ju, E., Liu, Z., Cao, F., Chen, Z., Ren, J., & Qu, X. (2018) · Nature Communications · doi:10.1038/s41467-018-05798-x · Cited by 646 · see citing works
Gao, M., Liang, C., Song, X., Chen, Q., Jin, Q., Wang, C., & Liu, Z. (2017) · Advanced Materials · doi:10.1002/adma.201701429 · Cited by 592 · see citing works
Zhu, W., Dong, Z., Fu, T., Liu, J., Chen, Q., Li, Y., Zhu, R., Xu, L., & Liu, Z. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201600676 · Cited by 590 · see citing works
Graham, K., & Unger, E. C. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s140462 · Cited by 581 · see citing works
Song, X., Feng, L., Liang, C., Yang, K., & Liu, Z. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b02365 · Cited by 581 · see citing works
Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future
Alzeibak, R., Mishchenko, T. A., Shilyagina, N. Y., Владимировна, Б. И., Vedunova, M. V., & Krysko, D. V. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001926 · Cited by 579 · see citing works
Two-photon excitation nanoparticles for photodynamic therapy
Shen, Y., Shuhendler, A. J., Ye, D., Xu, J., & Chen, H. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00442c · Cited by 569 · see citing works
Liu, C., Cao, Y., Cheng, Y., Wang, D., Xu, T., Su, L., Zhang, X., & Dong, H. (2020) · Nature Communications · doi:10.1038/s41467-020-15591-4 · Cited by 545 · see citing works
Self-citationOvercoming barriers in photodynamic therapy harnessing nano-formulation strategies
Xie, J., Wang, Y., Choi, W., Jangili, P., Ge, Y., Xu, Y., Kang, J., Liu, L., Zhang, B., Xie, Z., et al. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01370f · Cited by 526 · see citing works
Phthalocyanines as medicinal photosensitizers: Developments in the last five years
Li, X., Zheng, B.-D., Peng, X.-H., Li, S.-Z., Ying, J.-W., Zhao, Y., Huang, J., & Yoon, J. (2017) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.08.003 · Cited by 525 · see citing works
A Mitochondria‐Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia
Lv, W. Y., Zhang, Z., Zhang, K. Y., Yang, H., Liu, S., Xu, A., Guo, S., Zhao, Q., & Huang, W. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201604130 · Cited by 523 · see citing works
Jia, Q., Ge, J., Liu, W., Zheng, X., Chen, S., Wen, Y., Zhang, H., & Wang, P. (2018) · Advanced Materials · doi:10.1002/adma.201706090 · Cited by 511 · see citing works
Theranostic Fluorescent Probes
Sharma, A. K., Verwilst, P., Li, M., Ma, D., Singh, N., Yoo, J., Kim, Y., Yang, Y., Zhu, J., Huang, H., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00778 · Cited by 510 · see citing works
Pathological angiogenesis: mechanisms and therapeutic strategies
Dudley, A. C., & Griffioen, A. W. (2023) · Angiogenesis · doi:10.1007/s10456-023-09876-7 · Cited by 529 · see citing works
Zhang, C., Yan, K., Fu, C., Peng, H., Hawker, C. J., & Whittaker, A. K. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00632 · Cited by 493 · see citing works
Type I Photosensitizers Revitalizing Photodynamic Oncotherapy
Chen, D., Xu, Q., Wang, W., Shao, J., Huang, W., & Dong, X. (2021) · Small · doi:10.1002/smll.202006742 · Cited by 483 · see citing works
Wang, Y., Xie, Y., Li, J., Peng, Z., Sheinin, Y. M., Zhou, J., & Oupický, D. (2017) · ACS Nano · doi:10.1021/acsnano.6b08731 · Cited by 463 · see citing works
Chen, J., Luo, H., Liu, Y., Zhang, W., Li, H., Luo, T., Zhang, K., Zhao, Y., & Liu, J. (2017) · ACS Nano · doi:10.1021/acsnano.7b08225 · Cited by 453 · see citing works
Clinical Development of Metal Complexes as Photosensitizers for Photodynamic Therapy of Cancer
Karges, J. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202112236 · Cited by 446 · see citing works
Yao, C., Wang, W., Wang, P., Zhao, M., Li, X., & Zhang, F. (2018) · Advanced Materials · doi:10.1002/adma.201704833 · Cited by 447 · see citing works
Feng, L., Cheng, L., Dong, Z., Tao, D., Barnhart, T. E., Cai, W., Chen, M., & Liu, Z. (2016) · ACS Nano · doi:10.1021/acsnano.6b07525 · Cited by 425 · see citing works
Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment
Zhang, C., Wang, X., Du, J., Gu, Z., & Zhao, Y. (2020) · Advanced Science · doi:10.1002/advs.202002797 · Cited by 404 · see citing works
Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy
Zhou, Z., Song, J., Tian, R., Yáng, Z., Yu, G., Lin, L., Zhang, G., Fan, W., Zhang, F., Niu, G., et al. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201701181 · Cited by 385 · see citing works
Wang, D., Wu, H., Lim, W. Q., Phua, S. Z. F., Xu, P., Chen, Q., Guo, Z. G., & Zhao, Y. (2019) · Advanced Materials · doi:10.1002/adma.201901893 · Cited by 383 · see citing works
Photodynamic therapy for hypoxic tumors: Advances and perspectives
Li, H., Zhao, S., Wu, J., Yu, L., Singh, N., Yang, K., Lan, M., Wang, P., & Kim, J. S. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.213888 · Cited by 372 · see citing works
Self-citationWan, Q., Zhang, R., Zhuang, Z., Li, Y., Huang, Y., Wang, Z., Zhang, W., Hou, J., & Tang, B. Z. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202002057 · Cited by 365 · see citing works
Chen, Z., Liu, L., Liang, R., Luo, Z., He, H., Wu, Z., Tian, H., Zheng, M., Ma, Y., & Cai, L. (2018) · ACS Nano · doi:10.1021/acsnano.8b04371 · Cited by 364 · see citing works
Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy
Yu, L., Hu, P., & Chen, Y. (2018) · Advanced Materials · doi:10.1002/adma.201801964 · Cited by 361 · see citing works
Gas-Mediated Cancer Bioimaging and Therapy.
Chen, L., Zhou, S.-F., Su, L., & Song, J.-B. (2019) · ACS Nano · doi:10.1021/acsnano.9b04954 · Cited by 284 · see citing works
A Semiconducting Polymer Nano‐prodrug for Hypoxia‐Activated Photodynamic Cancer Therapy
Cui, D. M., Huang, J., Xu, Z. J., Li, J., Jiang, Y., & Pu, K. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201814730 · Cited by 342 · see citing works
Advances and perspectives in organic sonosensitizers for sonodynamic therapy
Xing, X., Zhao, S., Xu, T., Li, H., Zhang, Y., Lan, M., Lin, C., Zheng, X., & Wang, P. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214087 · Cited by 334 · see citing works
Yang, G., Phua, S. Z. F., Lim, W. Q., Zhang, R., Feng, L., Liu, G., Wu, H., Bindra, A. K., Jana, D., Liu, Z., et al. (2019) · Advanced Materials · doi:10.1002/adma.201901513 · Cited by 333 · see citing works
Nanomedicine for tumor microenvironment modulation and cancer treatment enhancement
Liu, J., Chen, Q., Feng, L., & Liu, Z. (2018) · Nano Today · doi:10.1016/j.nantod.2018.06.008 · Cited by 329 · see citing works
Recent Progress in Near Infrared Light Triggered Photodynamic Therapy
Deng, K., Li, C., Huang, S., Xing, B., Jin, D., Zeng, Q., Hou, Z., & Lin, J. (2017) · Small · doi:10.1002/smll.201702299 · Cited by 325 · see citing works
Liang, S., Deng, X., Xu, G., Xiao, X., Wang, M., Guo, X., Ma, P., Cheng, Z., Zhang, D., & Lin, J. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201908598 · Cited by 324 · see citing works
Fluoropolymers in Biomedical Applications: State-of-the-Art and Future Perspectives
Lv, J., & Cheng, Y. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00258e · Cited by 316 · see citing works
Self-citationManipulating tumor hypoxia toward enhanced photodynamic therapy (PDT)
Dang, J., He, H., Chen, D., & Yin, L. (2017) · Biomaterials Science · doi:10.1039/c7bm00392g · Cited by 317 · see citing works
Wu, M., Liu, X., Chen, H., Duan, Y., Liu, J., Pan, Y., & Liu, B. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202016399 · Cited by 317 · see citing works
Low temperature photothermal therapy: Advances and perspectives
Yang, K., Zhao, S., Li, B., Wang, B., Lan, M., & Song, X. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214330 · Cited by 311 · see citing works
Modulating Hypoxia via Nanomaterials Chemistry for Efficient Treatment of Solid Tumors
Liu, Y., Jiang, Y., Zhang, M., Tang, Z., He, M., & Bu, W. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.8b00214 · Cited by 308 · see citing works
Li, M., Li, L., Su, K., Liu, X., Zhang, T., Liang, Y., Jing, D., Yang, X., Zheng, D., Cui, Z., et al. (2019) · Advanced Science · doi:10.1002/advs.201900599 · Cited by 306 · see citing works
Lin, T., Zhao, X., Zhao, S., Yu, H., Cao, W., Chen, W., Wei, H., & Guo, H. (2018) · Theranostics · doi:10.7150/thno.22465 · Cited by 305 · see citing works
Advanced hybrid nanomaterials for biomedical applications
Park, W., Shin, H., Choi, B., Rhim, W.-K., Na, K., & Han, D. K. (2020) · Progress in Materials Science · doi:10.1016/j.pmatsci.2020.100686 · Cited by 300 · see citing works
Yang, X., Yang, Y., Gao, F., Wei, J., Qian, C., & Sun, M. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00934 · Cited by 293 · see citing works
Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor
Xu, S., Zhu, X., Zhang, C., Huang, W., Zhou, Y., & Yan, D. (2018) · Nature Communications · doi:10.1038/s41467-018-04318-1 · Cited by 292 · see citing works
Strategies for engineering advanced nanomedicines for gas therapy of cancer
Wang, Y., Yang, T., & He, Q. (2020) · National Science Review · doi:10.1093/nsr/nwaa034 · Cited by 292 · see citing works
Hu, P., Wu, T. S., Fan, W., Chen, L., Liu, Y., Ni, D., Bu, W., & Shi, J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.06.035 · Cited by 266 · see citing works
Recent progress on nanoparticle-based drug delivery systems for cancer therapy
Xin, Y., Yin, M., Zhao, L., Meng, F., & Luo, L. (2017) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2017.0052 · Cited by 265 · see citing works
Covalent Organic Frameworks as Favorable Constructs for Photodynamic Therapy
Zhang, L., Wang, S., Zhou, Y., Wang, C., Zhang, X., & Deng, H. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201909020 · Cited by 265 · see citing works
Gao, S., Wang, G., Qin, Z., Wang, X., Zhao, G., Ma, Q., & Zhu, L. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.030 · Cited by 260 · see citing works
Li, D., Yang, Y., Li, D., Pan, J., Chu, C., & Liu, G. (2021) · Small · doi:10.1002/smll.202101976 · Cited by 255 · see citing works
Sun, W. C., Li, S., Häupler, B., Liu, J., Jin, S., Steffen, W., Schubert, U. S., Butt, H., Liang, X., & Wu, S. (2016) · Advanced Materials · doi:10.1002/adma.201603702 · Cited by 252 · see citing works
Sun, Y., Zhao, D., Wang, G., Wang, Y., Cao, L., Sun, J., Jiang, Q., & He, Z. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.01.004 · Cited by 250 · see citing works
Wang, Y., Jin, Y., Chen, W., Wang, J., Chen, H., Sun, L. N., Li, X., Ji, J., Yu, Q., Shen, L., et al. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.10.002 · Cited by 245 · see citing works
Cao, Y., Dong, H., Yang, Z., Zhong, X., Chen, Y., Dai, W., & Zhang, X. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b13150 · Cited by 241 · see citing works
Song, G., Ji, C., Liang, C., Song, X., Yi, X., Dong, Z., Yang, K., & Liu, Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.020 · Cited by 238 · see citing works
Wang, Z., Ju, Y., Ali, Z., Yin, H. Y., Sheng, F., Lin, J., Wang, B., & Hou, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-12142-4 · Cited by 232 · see citing works
Recent advances in photonanomedicines for enhanced cancer photodynamic therapy
Hu, J., Lei, Q., & Zhang, X. (2020) · Progress in Materials Science · doi:10.1016/j.pmatsci.2020.100685 · Cited by 228 · see citing works
Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment
Shen, Z., Ma, Q., Zhou, X., Zhang, G., Hao, G., Sun, Y. Y., & Cao, J. (2021) · NPG Asia Materials · doi:10.1038/s41427-021-00303-1 · Cited by 227 · see citing works
Wu, Q., He, Z., Wang, X., Zhang, Q., Wei, Q., Ma, S., Ma, C., Li, J., & Wang, Q. (2019) · Nature Communications · doi:10.1038/s41467-018-08234-2 · Cited by 222 · see citing works
Nanoparticle‐based photothermal and photodynamic immunotherapy for tumor treatment
Hou, X., Tao, Y., Pang, Y., Li, X., Jiang, G., & Liu, Y. (2018) · International Journal of Cancer · doi:10.1002/ijc.31717 · Cited by 222 · see citing works
Biomimetic Liposomal Nanoplatinum for Targeted Cancer Chemophototherapy
Liu, X., Dong, X., Yang, S., Lai, X. P., Liu, H., Gao, Y., Feng, H., Zhu, M., Yuan, Y., Lu, Q., et al. (2021) · Advanced Science · doi:10.1002/advs.202003679 · Cited by 221 · see citing works
Liang, X., Chen, M., Bhattarai, P., Hameed, S., & Dai, Z. (2020) · ACS Nano · doi:10.1021/acsnano.0c05617 · Cited by 220 · see citing works
Ma, Z., Jia, X., Bai, J., Ruan, Y., Wang, C., Li, J., Zhang, M., & Jiang, X. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201604258 · Cited by 218 · see citing works
Improving cancer therapy through the nanomaterials-assisted alleviation of hypoxia
Sahu, A., Kwon, I., & Tae, G. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119578 · Cited by 218 · see citing works
Wang, J., Sun, J., Hu, W., Wang, Y., Chou, T., Zhang, B., Zhang, Q., Ren, L., & Wang, H. (2020) · Advanced Materials · doi:10.1002/adma.202001862 · Cited by 218 · see citing works
Li, B., Lin, L., Lin, H., & Wilson, B. C. (2016) · Journal of Biophotonics · doi:10.1002/jbio.201600055 · Cited by 215 · see citing works
Gao, S., Zheng, P., Li, Z., Feng, X., Yan, W., Chen, S., Guo, W., Liu, D., Yang, X., Wang, S., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.007 · Cited by 214 · see citing works
Cai, X., Xie, Z., Ding, B., Shao, S., Liang, S., Pang, M., & Lin, J. (2019) · Advanced Science · doi:10.1002/advs.201900848 · Cited by 212 · see citing works
RetractedSun, H., Xu, J., Wang, Y., Shen, S., Xu, X., Zhang, L., & Jiang, Q. Y. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.12.021 · Cited by 213 · see citing works
Hu, D., Chen, L., Qu, Y., Peng, J., Chu, B., Shi, K., Hao, Y., Zhong, L. X., Wang, M., & Qian, Z. (2018) · Theranostics · doi:10.7150/thno.22989 · Cited by 212 · see citing works
Yolk–Shell Nanostructures: Design, Synthesis, and Biomedical Applications
Lin, L., Song, J., Yang, H., & Chen, X. S. (2017) · Advanced Materials · doi:10.1002/adma.201704639 · Cited by 206 · see citing works
Tao, D., Feng, L., Chao, Y., Liang, C., Song, X., Wang, H., Yang, K., & Liu, Z. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201804901 · Cited by 206 · see citing works
Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management
Huo, D., Jiang, X., & Hu, Y. (2019) · Advanced Materials · doi:10.1002/adma.201904337 · Cited by 206 · see citing works
Self-citationRecent advances in innovative strategies for enhanced cancer photodynamic therapy
Hu, T., Wang, Z., Shen, W., Liang, R., Yan, D., & Wei, M. (2021) · Theranostics · doi:10.7150/thno.54227 · Cited by 210 · see citing works
Zhang, C., Chen, W., Liu, L., Qiu, W., Yu, W., & Zhang, X. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201700626 · Cited by 205 · see citing works
Sheng, D., Liu, T., Deng, L., Zhang, L., Li, X., Xu, J., Hao, L., Li, P., Ran, H., Chen, H., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.041 · Cited by 204 · see citing works
Modulating tumor hypoxia by nanomedicine for effective cancer therapy
Jahanban‐Esfahlan, R., de la Guardia, M., Ahmadi, D., & Yousefi, B. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25859 · Cited by 201 · see citing works
Photoconversion‐Tunable Fluorophore Vesicles for Wavelength‐Dependent Photoinduced Cancer Therapy
He, H., Ji, S., He, Y., Zhu, A., Zou, Y., Deng, Y., Ke, H., Yang, H., Zhao, Y., Guo, Z., et al. (2017) · Advanced Materials · doi:10.1002/adma.201606690 · Cited by 202 · see citing works
Tang, W., Yáng, Z., Wang, S., Wang, Z., Song, J., Yu, G., Fan, W., Dai, Y., Wang, J., Shan, L., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b08628 · Cited by 202 · see citing works
Zou, J., Zhu, J., Yáng, Z., Li, L., Fan, W., He, L., Tang, W., Deng, L., Mu, J., Ma, Y., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201914384 · Cited by 202 · see citing works
Self-citationWan, G., Chen, B., Li, L., Wang, D., Shi, S., Zhang, T., Wang, Y., Zhang, L., & Wang, Y. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.002 · Cited by 199 · see citing works
Huo, M., Wang, L., Zhang, L., Wei, C., Chen, Y., & Shi, J. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201912824 · Cited by 200 · see citing works
Lu, N., Fan, W., Yi, X., Wang, S., Wang, Z., Tian, R., Jacobson, O., Liu, Y., Yung, B. C., Zhang, G., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b08103 · Cited by 199 · see citing works
Zhang, L., Yi, H., Song, J., Huang, J., Yang, K., Tan, B., Wang, D., Yang, N., Wang, Z., & Li, X. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b21968 · Cited by 196 · see citing works
Ye, S., Rao, J., Qiu, S., Zhao, J., He, H., Yan, Z., Yang, T., Deng, Y., Ke, H., Yang, H., et al. (2018) · Advanced Materials · doi:10.1002/adma.201801216 · Cited by 194 · see citing works
Bifunctional Platinated Nanoparticles for Photoinduced Tumor Ablation
Guo, Z., Zou, Y., He, H., Rao, J., Ji, S., Cui, X., Ke, H., Deng, Y., Yang, H., Chen, C., et al. (2016) · Advanced Materials · doi:10.1002/adma.201602738 · Cited by 193 · see citing works
Chen, D., Yu, Q. B., Huang, X., Dai, H., Luo, T., Shao, J., Chen, P., Chen, J., Huang, W., & Dong, X. (2020) · Small · doi:10.1002/smll.202001059 · Cited by 193 · see citing works
- Authors
- Cheng, Y., Cheng, H., Jiang, C., Qiu, X., Wang, K., Huan, W., Yuan, A., Wu, J., & Hu, Y.
- Affiliations
- State Key Laboratory of Pharmaceutical Biotechnology (CN)
- Corresponding author
- Wu, Jinhui
- Hu, Yiqiao
- Venue
- Nature Communications
- Published
- 2015-11-03
- Volume
- 6
- Issue
- 1
- Pages
- 8785-8785
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4659941
- OpenAlex
- W2256492013
- Cited by
- 941
- References
- 25
- Citations by year
- 2026: 39 · 2025: 45 · 2024: 68 · 2023: 96 · 2022: 119 · 2021: 136 · 2020: 137 · 2019: 119 · 2018: 101 · 2017: 56 · 2016: 25
- FWCI
- 48.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province (BE2015674)
- Qinglan Project of Jiangsu Province of China
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Keywords
- photodynamic therapy, perfluorocarbon nanodroplets, photosensitizer delivery, tumor hypoxia, reactive oxygen species, singlet oxygen, tumor oxygenation, tumor growth inhibition, intravenous injection, cancer therapy
- MeSH terms
- Adenocarcinoma, Animals, Hypoxia, Breast Neoplasms, Cell Survival, Colonic Neoplasms, Female, Fluorocarbons, Humans, Male, Neoplasm Transplantation, Oxygen Consumption, Photochemotherapy, Apoptosis, Photosensitizing Agents, Reactive Oxygen Species, In Situ Nick-End Labeling, Singlet Oxygen, Cell Line, Tumor, Tumor Burden, Mice, Nanoparticles, MCF-7 Cells, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
