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Synthesis and Characterization of Thermoresponsive Hydrogels Based on N -Isopropylacrylamide Crosslinked with 4,4′-Dihydroxybiphenyl Diacrylate
Open accessAbstract
A novel crosslinker [4,4′-dihydroxybiphenyl diacrylate (44BDA)] was developed, and a series of temperature-responsive hydrogels were synthesized through free radical polymerization of N-isopropylacrylamide (NIPAAm) with 44BDA. The temperature-responsive behavior of the resulting gels was characterized by swelling studies, and the lower critical solution temperature (LCST) of the hydrogels was characterized through differential scanning calorimetry. Increased content of 44BDA led to a decreased swelling ratio and shifted the LCST to lower temperatures. These novel hydrogels also displayed resiliency through multiple swelling–deswelling cycles, and their temperature responsiveness was reversible. The successful synthesis of NIPAAm-based hydrogels crosslinked with 44BDA has led to a new class of temperature-responsive hydrogel systems with a variety of potential applications.
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The synthetic thermoresponsive polymers mainly pNIPAAm and PF127 are widely used for drug delivery applications because they can form gels near the body temperature of 37 °C.
“The synthetic thermoresponsive polymers mainly poly(N-isopropylacrylamide) (pNIPAAm) and pluronic F127 (PF127) are widely used for drug delivery applications since they can form gels near the body temperature of 37 °C [35,36,37].”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [37]
The Introduction (page not provided) describes NIPAAm-based hydrogels as useful for drug delivery and says biomedical applications often require a transition temperature near body temperature. It gives their typical transition temperature as 32 °C, however, and does not discuss PF127 or establish that either polymer forms gels near 37 °C. (LLM, conf=0.85)
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Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application
CHATTERJEE, S., & Chi-leung HUI, P. (2019) · Molecules · doi:10.3390/molecules24142547 · Cited by 201
Metadata
- Authors
- Tang, S., Floy, M., Bhandari, R., Sunkara, M., Morris, A. J., Dziubla, T. D., & Hilt, J. Z.
- Affiliations
- University of Kentucky (US)
- Kansas State University (US)
- Corresponding author
- Hilt, J. Zach
- ORCID
- Venue
- ACS Omega
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-12-07
- Volume
- 2
- Issue
- 12
- Pages
- 8723-8729
- ISSN
- 2470-1343 (ISSN-L)
- PMC
- PMC5748278
- OpenAlex
- W2773736701
- Cited by
- 33
- References
- 43
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 3
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- ACS Omega (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UKnowledge (University of Kentucky) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute of Environmental Health Sciences (P42ES007380)
- Division of Engineering Education and Centers (EEC-1460486)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- thermosensitive hydrogel, N-isopropylacrylamide, crosslinking agents, lower critical solution temperature, swelling behavior, radical polymerization, resilience engineering
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