In Vitro Investigation of Enhanced Hemocompatibility and Endothelial Cell Proliferation Associated with Quinone-Rich Polydopamine Coating
Abstract
Recent investigations have demonstrated that polydopamine (PDA)-modified surfaces were beneficial to the proliferation of endothelial cells (ECs). In this work, PDA coated 316L stainless steels (316L SS) were thermally treated at 50, 100, and 150 °C respectively (hereafter designated as Th50, Th100, and Th150) and consequently produced diverse surface chemical components. In vitro hemocompatibility and vascular cell-material interactions with ECs and smooth muscle cells (SMCs) affected by surface characteristics have been investigated. The Th150, rich in quinone, showed the best hemocompatibility and could effectively inhibit platelet adhesion, activation, and fibrinogen conformation transition. The polydopamine-modified surfaces were found to induce dramatic cell-material interaction with enhanced ECs proliferation, viability and migration, release of nitric oxide (NO), and reduced SMCs proliferation. The inhibitory effect of SMCs proliferation might be associated with the surface catechol content. The coating on Th150 showed a good resistance to the deformation of compression and expansion of vascular stents. These results effectively suggested that the Th150 coating might be promising when served as a stent coating platform.
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The activity of biomolecules adhered via the polydopamine coating layer is not affected by the polydopamine coating layer itself, except by the forming condition of the polydopamine coating layer and the inherent properties of the biomolecules (incubation time, concentration, molecule weight, and isoelectric point).
“Studies have shown that the activity of these biomolecules was not affected by the PDA coating layer itself except for the forming condition of PDA coating layer and the inherent properties of biomolecules (incubation time, concentration, molecule weight, and isoelectric point) [78].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [78]
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Chuah, Y. J., Koh, Y. T., Lim, K., Menon, N. V., Wu, Y., & Kang, Y. (2015) · Scientific Reports · doi:10.1038/srep18162 · Cited by 262 · see citing works
Polydopamine-Assisted Surface Modification for Bone Biosubstitutes
Huang, S., Liang, N., Hu, Y., Zhou, X., & Abidi, N. (2016) · BioMed Research International · doi:10.1155/2016/2389895 · Cited by 97 · see citing works
“For example, modulating the incubation temperature of DA (PDA precursor) could result in the improvement of the ratio of quinone versus phenolic hydroxyl groups to better regulate the proliferation of smooth muscle cells attached on the biosubstitutes [77].”
Background
- Authors
- Luo, R., Tang, L., Zhong, S., Yang, Z., Wang, J., Weng, Y., Tu, Q., Jiang, C., & Huang, N.
- Affiliations
- Southwest Jiaotong University (CN)
- Corresponding author
- Wang, Jin
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-02-19
- Volume
- 5
- Issue
- 5
- Pages
- 1704-1714
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2324730467
- Cited by
- 212
- References
- 0
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 19 · 2023: 22 · 2022: 15 · 2021: 16 · 2020: 25 · 2019: 17 · 2018: 22 · 2017: 15 · 2016: 14 · 2015: 19 · 2014: 7 · 2013: 5
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Keywords
- polydopamine coating, 316L stainless steel, hemocompatibility, endothelial cell proliferation, smooth muscle cell proliferation, platelet adhesion, nitric oxide release, heat treatment, surface modification
- MeSH terms
- Cell Adhesion, Cell Survival, Humans, Indoles, Materials Testing, Polymers, Benzoquinones, Cell Culture Techniques, Coated Materials, Biocompatible, Myocytes, Smooth Muscle, Endothelial Cells, Cell Proliferation
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