The DOI matches its Crossref record.
Regulation of the Biological Functions of Osteoblasts and Bone Formation by Zn-Incorporated Coating on Microrough Titanium
Abstract
To improve the biological performance of titanium implant, a series of Zn-incorporated coatings were fabricated on the microrough titanium (Micro-Ti) via sol-gel method by spin-coating technique. The successful fabrication of the coating was verified by combined techniques of scanning electron microscopy, surface profiler, X-ray diffraction, X-ray photoelectron spectroscopy, and water contact angle measurements. The incorporated zinc existed as ZnO, which released Zn ions in a sustained manner. The Zn-incorporated samples (Ti-Zn0.08, Ti-Zn0.16, and Ti-Zn0.24) efficiently inhibited the adhesion of both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria. The in vitro evaluations including cell activity, alkaline phosphatase (ALP), mineralization, osteogenic genes expressions (Runx2, ALP, OPG, Col I, OPN, and OC), and tartrate-resistant acid phosphatase, confirmed that Ti-Zn0.16 sample was the optimal one to regulate the proliferation or differentiation for both osteoblasts and osteoclasts. More importantly, in vivo evaluations including Micro-CT analysis, push-out test, and histological observations verified that Ti-Zn0.16 implants could efficiently promote new bone formation after implantation for 4 and 12 weeks, respectively. The resulting material thus has potential application in orthopedic field.
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Cited by
Yin, M., Wu, J., Deng, M., Wang, P., Ji, G., Wang, M., Zhou, C., Blum, N. T., Zhang, W., Shi, H., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c06036 · Cited by 380
Li, J., Tan, L., Liu, X., Cui, Z., Yang, X., Yeung, K. W. K., Chu, P. K., & Wu, S. (2017) · ACS Nano · doi:10.1021/acsnano.7b05620 · Cited by 300
Self-citationYang, H., Qu, X., Lin, W., Wang, C., Zhu, D., Dai, K., & Zheng, Y. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.03.007 · Cited by 284
Tao, B., Zhao, W., Lin, C., Yuan, Z., He, Y., Lu, L., Chen, M., Ding, Y., Yang, Y., Xia, Z., et al. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.124621 · Cited by 206
Self-citationBiodegradable bone implants as a new hope to reduce device-associated infections-a systematic review
Paiva, J. C. C., Oliveira, L., Vaz, M. F., & Costa-de-Oliveira, S. (2022) · Bioengineering · doi:10.3390/bioengineering9080409 · Cited by 53
Metadata
- Authors
- Shen, X., Hu, Y., Xu, G., Chen, W., Xu, K., Ran, Q., Ma, P., Zhang, Y., Li, J., & Cai, K.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-08-29
- Volume
- 6
- Issue
- 18
- Pages
- 16426-16440
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2319753713
- Cited by
- 179
- References
- 0
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shen, X., Hu, Y., Xu, G., Chen, W., Xu, K., Ran, Q., Ma, P., Zhang, Y., Li, J., & Cai, K. (2014). Regulation of the Biological Functions of Osteoblasts and Bone Formation by Zn-Incorporated Coating on Microrough Titanium. ACS Applied Materials & Interfaces. https://doi.org/10.1021/am5049338
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