Multifunctional magnesium organic framework-based microneedle patch for accelerating diabetic wound healing
Abstract
Abstract Diabetic wound healing is one of the major challenges in the biomedical fields. The conventional single drug treatments have unsatisfactory efficacy, and the drug delivery effectiveness is restricted by the penetration depth. Herein, we develop a magnesium organic framework-based microneedle patch (denoted as MN-MOF-GO-Ag) that can realize transdermal delivery and combination therapy for diabetic wound healing. Multifunctional magnesium organic frameworks (Mg-MOFs) are mixed with poly(γ-glutamic acid) (γ-PGA) hydrogel and loaded into the tips of MN-MOF-GO-Ag, which slowly releases Mg2+ and gallic acid in the deep layer of the dermis. The released Mg2+ induces cell migration and endothelial tubulogenesis, while gallic acid, a reactive oxygen species-scavenger, promotes antioxidation. Besides, the backing layer of MN-MOF-GO-Ag is made of γ-PGA hydrogel and graphene oxide-silver nanocomposites (GO-Ag) which further enables excellent antibacterial effects for accelerating wound healing. The therapeutic effects of MN-MOF-GO-Ag on wound healing are demonstrated with the full-thickness cutaneous wounds of a diabetic mouse model. The significant improvement of wound healing is achieved for mice treated with MN-MOF-GO-Ag.
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Mg-GA MOF was successfully synthesized.
“The successful synthesis of Mg-GA MOF was further demonstrated by X-ray diffraction (XRD) and the routine XRD pattern were shown in Fig. 2B, which was consistent with previous reports [42,43].”
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Kang, Y., Xu, C., Meng, L., Dong, X., Qi, M., & Jiang, D. (2022) · Bioactive materials · doi:10.1016/j.bioactmat.2022.02.012 · Cited by 253 · see citing works
- Authors
- Yin, M., Wu, J., Deng, M., Wang, P., Ji, G., Wang, M., Zhou, C., Blum, N. T., Zhang, W., Shi, H., Jia, N., Wang, X., & Huang, P.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Shenzhen University (CN)
- Shanghai Normal University (CN)
- Corresponding author
- Zhang, Wenjie
- Jia, Nengqin
- Wang, Xiansong
- Huang, Peng
- ORCID
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-11-11
- Volume
- 15
- Issue
- 11
- Pages
- 17842-17853
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W3213604708
- Cited by
- 380
- References
- 59
- Citations by year
- 2026: 58 · 2025: 91 · 2024: 104 · 2023: 92 · 2022: 34 · 2021: 1
- FWCI
- 30.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shanghai Municipal Health Commission (2019CXJQ01)
- National Natural Science Foundation of China (31971271, 81671839)
- Basic Research Program of Shenzhen (JCYJ20170412111100742, JCYJ20180507182413022, JCYJ20200109105620482)
- Shenzhen Science and Technology Program (KQTD20190929172538530)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- microneedle patch, diabetic wound healing, transdermal drug delivery, gallic acid, magnesium ion release, antibacterial wound dressing, reactive oxygen species scavenging, endothelial tubulogenesis, combination therapy
- MeSH terms
- Animals, Anti-Bacterial Agents, Diabetes Mellitus, Gallic Acid, Magnesium, Wound Healing, Hydrogels, Mice
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