The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Ratiometric Fluorescent Probe Based on ESIPT and AIE Processes for Alkaline Phosphatase Activity Assay and Visualization in Living Cells
Abstract
Alkaline phosphatase (ALP) activity is regarded as an important biomarker in medical diagnosis. A ratiometric fluorescent probe is developed based on a phosphorylated chalcone derivative for ALP activity assay and visualization in living cells. The probe is soluble in water and emits greenish-yellow in aqueous buffers. In the presence of ALP, the emission of probe changes to deep red gradually with ratiometric fluorescent response due to formation and aggregation of enzymatic product, whose fluorescence involves both excited-state intramolecular proton transfer and aggregation-induced emission processes. The linear ratiometric fluorescent response enables in vitro quantification of ALP activity in a range of 0-150 mU/mL with a detection limit of 0.15 mU/mL. The probe also shows excellent biocompatibility, which enables it to apply in ALP mapping in living cells.
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Hong, Y., Lam, J. W. Y., & Tang, B. Z. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15113d · Cited by 6,363
Self-citationRapid Detection of Hydrogen Peroxide Based on Aggregation Induced Ratiometric Fluorescence Change
Li, G., Zhu, D., Liu, Q., Xue, L., & Jiang, H. (2013) · Organic Letters · doi:10.1021/ol4000845 · Cited by 98
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Specific light-up bioprobes based on AIEgen conjugates
Liang, J., Tang, B. Z., & Liu, B. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00444b · Cited by 762
Self-citationAggregation-Induced Emission Luminogens for Activity-Based Sensing
Wang, D., & Tang, B. Z. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00305 · Cited by 510
Self-citationPolymeric AIE-based nanoprobes for biomedical applications: recent advances and perspectives
Zhang, X., Wang, K., Liu, M., Zhang, X., Tao, L., Chen, Y., & Wei, Y. (2015) · Nanoscale · doi:10.1039/c5nr01444a · Cited by 508
Fluorescent chemosensors manipulated by dual/triple interplaying sensing mechanisms
He, L., Dong, B., Liu, Y., & Lin, W. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00413j · Cited by 455
Metadata
- Authors
- Song, Z., Kwok, R. T. K., Zhao, E., He, Z., Hong, Y., Lam, J. W. Y., Liu, B., & Tang, B. Z.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-09-24
- Volume
- 6
- Issue
- 19
- Pages
- 17245-17254
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2068615956
- Cited by
- 325
- References
- 2
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- closed
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