The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Solvation and Hydration of Proteins and Nucleic Acids: A Theoretical View of Simulation and Experiment
Abstract
Many theoretical, computational, and experimental techniques recently have been successfully used for description of the solvent distribution around macromolecules. In this Account, we consider recent developments in the areas of protein and nucleic acid solvation and hydration as seen by experiment, theory, and simulations. We find that in most cases not only the general phenomena of solvation but even local hydration patterns are more accurately discussed in the context of water distributions rather than individual molecules of water. While a few localized or high-residency waters are often associated with macromolecules in solution (or crystals from aqueous liquors), these are readily and accurately included in this more general description. The goal of this Account is to review the theoretical models used for the description of the interfacial solvent structure on the border near DNA and protein molecules. In particular, we hope to highlight the progress in this field over the past five years with a focus on comparison of simulation and experimental results.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Principles of Nucleic Acid Structure
(2008) · Elsevier eBooks · doi:10.1016/b978-0-12-369507-9.x5001-8 · Cited by 4,504
Principles of Nucleic Acid Structure
Saenger, W. (1984) · Springer Advanced Texts in Chemistry · doi:10.1007/978-1-4612-5190-3 · Cited by 4,150
Temporal Processing Deficits of Language-Learning Impaired Children Ameliorated by Training
Merzenich, M. M., Jenkins, W. M., Johnston, P., Schreiner, C., Miller, S. L., & Tallal, P. (1996) · Science · doi:10.1126/science.271.5245.77 · Cited by 1,000
Protein hydration in solution: Experimental observation by x-ray and neutron scattering
Svergun, D. I., Richard, S., Koch, M. H. J., Sayers, Z., Kuprin, S., & Zaccai, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2267 · Cited by 912
Hummer, G., Garde, S., García, A. E., Paulaitis, M. E., & Pratt, L. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1552 · Cited by 591
Deisenhofer, J., & Steigemann, W. (1975) · Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry · doi:10.1107/s0567740875002415 · Cited by 546
(1988) · Advances in Chemical Physics · doi:10.1002/9780470141205 · Cited by 499
Ordered water structure around a B-DNA dodecamer
Kopka, M. L., Fratini, A. V., Drew, H. R., & Dickerson, R. E. (1983) · Journal of Molecular Biology · doi:10.1016/0022-2836(83)90033-5 · Cited by 488
The B-DNA Dodecamer at High Resolution Reveals a Spine of Water on Sodium,
Shui, X., McFail-Isom, L., Hu, G. G., & Williams, L. D. (1998) · Biochemistry · doi:10.1021/bi973073c · Cited by 404
Protein Hydration Observed by X-ray Diffraction
Jiang, J.-S., & Brünger, A. T. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1633 · Cited by 350
Cited by
Water as an active constituent in cell biology
Ball, P. (2008) · Chemical Reviews · doi:10.1021/cr068037a · Cited by 2,177
WATER MEDIATION IN PROTEIN FOLDING AND MOLECULAR RECOGNITION
Levy, Y., & Onuchic, J. N. (2006) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.040405.102134 · Cited by 1,048
Role of molecular charge and hydrophilicity in regulating the kinetics of crystal growth
Elhadj, S., De Yoreo, J. J., Hoyer, J. R., & Dove, P. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605748103 · Cited by 270
Metadata
- Authors
- Makarov, V., Pettitt, B. M., & Feig, M.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-03-08
- Volume
- 35
- Issue
- 6
- Pages
- 376-384
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2005739967
- Cited by
- 340
- References
- 40
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Solvation and Hydration of Proteins and Nucleic Acids: A Theoretical View of Simulation and Experiment. https://app.cochat.ai/papers/10.1021/ar0100273
- The paper
- Makarov, V., Pettitt, B. M., & Feig, M. (2002). Solvation and Hydration of Proteins and Nucleic Acids: A Theoretical View of Simulation and Experiment. Accounts of Chemical Research. https://doi.org/10.1021/ar0100273
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
