The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
WATER MEDIATION IN PROTEIN FOLDING AND MOLECULAR RECOGNITION
Abstract
Water is essential for life in many ways, and without it biomolecules might no longer truly be biomolecules. In particular, water is important to the structure, stability, dynamics, and function of biological macromolecules. In protein folding, water mediates the collapse of the chain and the search for the native topology through a funneled energy landscape. Water actively participates in molecular recognition by mediating the interactions between binding partners and contributes to either enthalpic or entropic stabilization. Accordingly, water must be included in recognition and structure prediction codes to capture specificity. Thus water should not be treated as an inert environment, but rather as an integral and active component of biomolecular systems, where it has both dynamic and structural roles. Focusing on water sheds light on the physics and function of biological machinery and self-assembly and may advance our understanding of the natural design of proteins and nucleic acids.
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Cites
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Cited by
Water Dynamics in the Hydration Shells of Biomolecules
Laage, D., Elsaesser, T., & Hynes, J. T. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00765 · Cited by 913
On the Molecular Mechanism of Water Reorientation
Laage, D., & Hynes, J. T. (2008) · The Journal of Physical Chemistry B · doi:10.1021/jp805217u · Cited by 438
Guedes, I. A., Pereira, F. S. S., & Dardenne, L. E. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01089 · Cited by 331
Martin-Jimenez, D., Chacon, E., Tarazona, P., & Garcia, R. (2016) · Nature Communications · doi:10.1038/ncomms12164 · Cited by 198
Energy landscape in protein folding and unfolding
Mallamace, F., Corsaro, C., Mallamace, D., Vasi, S., Vasi, C., Baglioni, P., Buldyrev, S. V., Chen, S.-H., & Stanley, H. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524864113 · Cited by 122
Metadata
- Authors
- Levy, Y., & Onuchic, J. N.
- Venue
- Annual Review of Biophysics and Biomolecular Structure
- Publisher
- Annual Reviews
- Published
- 2006-06-01
- Volume
- 35
- Issue
- 1
- Pages
- 389-415
- ISSN
- 1056-8700 (ISSN-L)
- 1545-4266
- OpenAlex
- W2104529244
- Cited by
- 1,048
- References
- 132
- FWCI
- 15.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Levy, Y., & Onuchic, J. N. (2006). WATER MEDIATION IN PROTEIN FOLDING AND MOLECULAR RECOGNITION. Annual Review of Biophysics and Biomolecular Structure. https://doi.org/10.1146/annurev.biophys.35.040405.102134
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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