The DOI matches its Crossref record.
PARACEST Agents: Modulating MRI Contrast via Water Proton Exchange
Abstract
Scientific interest in optimizing the properties of gadolinium (III) complexes as MRI contrast agents has led to many new insights into lanthanide ion coordination chemistry in the last two decades. Among these was the surprising observation that water exchange in lanthanide (III) derivatives of DOTA can be modulated dramatically by judicious choice of ligand side chain and Ln(3+) ionic radii. This resulted in the discovery of paramagnetic CEST agents for altering MRI image contrast based upon the chemical exchange saturation transfer mechanism. The goal of this article is to review the factors that govern water molecule and water proton exchange in these complexes and to compare the potential sensitivity of PARACEST agents versus Gd(3+)-based T(1) relaxation agents for altering tissue contrast.
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Chemical exchange saturation transfer (CEST): what is in a name and what isn't?
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Gd(III)-BASED CONTRAST AGENTS FOR MRI
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Zaiss, M., & Bachert, P. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/22/r221 · Cited by 323
Hashim, A. I., Zhang, X., Wojtkowiak, J. W., Martinez, G. V., & Gillies, R. J. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1644 · Cited by 265
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Metadata
- Authors
- Zhang, S., Merritt, M., Woessner, D. E., Lenkinski, R. E., & Sherry, A. D.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-08-14
- Volume
- 36
- Issue
- 10
- Pages
- 783-790
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2117349353
- Cited by
- 436
- References
- 0
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- closed
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