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New hydrazone derivatives of Adriamycin and their immunoconjugates - a correlation between acid stability and cytotoxicity
Abstract
New N-substituted hydrazine linkers were synthesized and their hydrazone derivatives of adriamycin were prepared. These functionalized adriamycin derivatives were conjugated with a monoclonal antibody, 5E9. The release rate of adriamycin from the hydrazones and from some of the conjugates was studied, and their relationship to the IC50's of the conjugate against 5E9-positive Daudi cells was investigated.
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Citations
Cited by
Bae, Y., Fukushima, S., Harada, A., & Kataoka, K. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200250653 · Cited by 1,329
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Chilkoti, A., Dreher, M. R., Meyer, D. E., & Raucher, D. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00041-8 · Cited by 573
Polyester Dendritic Systems for Drug Delivery Applications: In Vitro and In Vivo Evaluation
Padilla De Jesús, O. L., Ihre, H. R., Gagne, L., Fréchet, J. M. J., & Szoka, F. C. (2002) · Bioconjugate Chemistry · doi:10.1021/bc010103m · Cited by 507
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Ulbrich, K. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.040 · Cited by 494
Polyester Dendritic Systems for Drug Delivery Applications: Design, Synthesis, and Characterization
Ihre, H. R., Padilla De Jesús, O. L., Szoka, & Fréchet, J. M. J. (2002) · Bioconjugate Chemistry · doi:10.1021/bc010102u · Cited by 332
Metadata
- Authors
- Kaneko, T., Willner, D., Monkovic, I., Knipe, J. O., Braslawsky, G. R., Greenfield, R. S., & Vyas, D. M.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1991-05-01
- Volume
- 2
- Issue
- 3
- Pages
- 133-141
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W2009909078
- Cited by
- 163
- References
- 0
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: New hydrazone derivatives of Adriamycin and their immunoconjugates - a correlation between acid stability and cytotoxicity. https://app.cochat.ai/papers/10.1021/bc00009a001
- The paper
- Kaneko, T., Willner, D., Monkovic, I., Knipe, J. O., Braslawsky, G. R., Greenfield, R. S., & Vyas, D. M. (1991). New hydrazone derivatives of Adriamycin and their immunoconjugates - a correlation between acid stability and cytotoxicity. Bioconjugate Chemistry. https://doi.org/10.1021/bc00009a001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
