The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Polyester Dendritic Systems for Drug Delivery Applications: Design, Synthesis, and Characterization
Abstract
Attachment of drugs to high molecular weight polymers can significantly improve both tumor targeting and therapeutic efficacy due to the enhanced permeability and retention effect observed in tumor tissue. However, the commercial availability of well-defined water-soluble polymeric systems with narrow polydispersities that are biocompatible, nontoxic, and nonimmunogenic is rather limited. To address this need, we have investigated dendritic polymers as promising scaffolds for the preparation of new soluble polymeric drug carriers due to their well-defined molecular architecture and their multiplicity of surface sites. Herein we show the design and synthesis of dendritic polyester systems based on the monomer unit 2,2-bis(hydroxymethyl)propanoic acid as a possible versatile drug carrier. The potent anticancer drug doxorubicin was attached via a pH-sensitive linkage to one of the carriers presented, demonstrating the feasibility of using these polyester dendritic structures to prepare a viable polymer-drug conjugate.
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Cites
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Cited by
Bae, Y., Fukushima, S., Harada, A., & Kataoka, K. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200250653 · Cited by 1,329
Dendrimer toxicity: Let's meet the challenge
Jain, K., Kesharwani, P., Gupta, U., & Jain, N. K. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.04.027 · Cited by 710
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Multifunctional and stimuli-sensitive pharmaceutical nanocarriers
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Polyester Dendritic Systems for Drug Delivery Applications: In Vitro and In Vivo Evaluation
Padilla De Jesús, O. L., Ihre, H. R., Gagne, L., Fréchet, J. M. J., & Szoka, F. C. (2002) · Bioconjugate Chemistry · doi:10.1021/bc010103m · Cited by 507
Self-citation
Metadata
- Authors
- Ihre, H. R., Padilla De Jesús, O. L., Szoka, & Fréchet, J. M. J.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-04-24
- Volume
- 13
- Issue
- 3
- Pages
- 443-452
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W2031780453
- Cited by
- 332
- References
- 40
- FWCI
- 21.92
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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