The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Biodegradable Polymers for Protein and Peptide Drug Delivery
Abstract
We have reviewed a large cross-section of degradable polymeric delivery systems for protein and peptide pharmaceuticals. These systems include monolithic type devices in which the drug is dispersed throughout the polymer and protein-polymer conjugates where the drug is covalently bound to the polymer. These delivery systems have unique challenges associated with their development that are related to both protein stability and protein release kinetics. Despite numerous reports in the scientific literature which include many encouraging results in preclinical models, very few of these systems have been developed into viable products. The products that have made it to market, however, have proven to be very successful and demonstrate the significant advantages that these systems can provide. The continuous advances in biotechnology will produce more proteins and peptides that will be difficult to administer by conventional means, and an increased demand for controlled or site-specific delivery systems is anticipated.
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Citations
Cites
Langer, R. (1990) · Science · doi:10.1126/science.2218494 · Cited by 1,778
Degradation of poly (D,L-lactic acid) microspheres: Effect of molecular weight
Park, T. G. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90263-1 · Cited by 359
Biodegradable PEO/PLA block copolymers
Cohn, D., & Younes, H. (1988) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820221104 · Cited by 241
Cited by
de Jong, S. J., van Dijk-Wolthuis, W. N. E., Kettenes-van den Bosch, J. J., Schuyl, P. J. W., & Hennink, W. E. (1998) · Macromolecules · doi:10.1021/ma980553i · Cited by 172
Metadata
- Authors
- Gombotz, W. R., & Pettit, D. K.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1995-07-01
- Volume
- 6
- Issue
- 4
- Pages
- 332-351
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W1993135217
- Cited by
- 448
- References
- 3
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
