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Cited by 625

The DOI matches its Crossref record.

Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies

Ducry, Laurent, Stump, Bernhard·2010·Bioconjugate Chemistry
DOI 10.1021/bc9002019
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Abstract

Antibody-drug conjugates (ADCs) combine the specificity of monoclonal antibodies (mAbs) with the potency of cytotoxic molecules, thereby taking advantage of the best characteristics of both components. Along with the development of the mAbs and cytotoxins, the design of chemical linkers to covalently bind these building blocks is making rapid progress but remains challenging. Recent advances have resulted in linkers having increased stability in the bloodstream while allowing efficient payload release within the tumor cell.

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Metadata

Authors
Ducry, L., & Stump, B.
Venue
Bioconjugate Chemistry
Publisher
American Chemical Society (ACS)
Published
2009-09-21
Volume
21
Issue
1
Pages
5-13
ISSN
  • 1043-1802 (ISSN-L)
  • 1520-4812
DOI
10.1021/bc9002019
OpenAlex
W2058332629
Cited by
625
References
0
FWCI
15.74
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies. https://app.cochat.ai/papers/10.1021/bc9002019
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Ducry, L., & Stump, B. (2010). Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies. Bioconjugate Chemistry. https://doi.org/10.1021/bc9002019

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.