The DOI matches its Crossref record.
Antimicrobial Peptide Pores in Membranes Detected by Neutron In-Plane Scattering
Abstract
Antimicrobial peptides isolated from the host defense systems of animals have been shown to exert their activity directly on the lipid bilayer of cell membranes, but the antimicrobial mechanisms are not clear, due chiefly to the difficulty of discerning the high-order structures formed by these peptides in membranes. Previously we have shown that these peptides insert into the membrane when their concentrations exceed a lipid-dependent critical value. With neutron in-plane scattering we now show that inserted alamethicin creates aqueous pores approximately greater than 18 A in diameter. The density of pores is consistent with the assumption that all of the alamethicin is involved in pore formation. Pores were not detected below the critical concentration. Thus concentration-dependent pore formation appears to be the molecular mechanism of antimicrobial action.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Brogden, K. A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1098 · Cited by 5,829
Barrel-Stave Model or Toroidal Model? A Case Study on Melittin Pores
Yang, L., Harroun, T. A., Weiss, T. M., Ding, L., & Huang, H. W. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)75802-x · Cited by 1,114
Self-citationSato, H., & Feix, J. B. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.02.021 · Cited by 522
Evidence for Membrane Thinning Effect as the Mechanism for Peptide-Induced Pore Formation
Chen, F.-Y., Lee, M.-T., & Huang, H. W. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)75103-0 · Cited by 295
Self-citationAssembly and Stability of Nisin−Lipid II Pores
Hasper, H. E., de Kruijff, B., & Breukink, E. (2004) · Biochemistry · doi:10.1021/bi049476b · Cited by 271
Metadata
- Authors
- He, K., Ludtke, S. J., Huang, H. W., & Worcester, D. L.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1995-12-05
- Volume
- 34
- Issue
- 48
- Pages
- 15614-15618
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W1977700675
- Cited by
- 178
- References
- 0
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Antimicrobial Peptide Pores in Membranes Detected by Neutron In-Plane Scattering. https://app.cochat.ai/papers/10.1021/bi00048a002
- The paper
- He, K., Ludtke, S. J., Huang, H. W., & Worcester, D. L. (1995). Antimicrobial Peptide Pores in Membranes Detected by Neutron In-Plane Scattering. Biochemistry. https://doi.org/10.1021/bi00048a002
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
