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Structural Mechanisms for Domain Movements in Proteins
Abstract
We survey all the known instances of domain movements in proteins for which there is crystallographic evidence for the movement. We explain these domain movements in terms of the repertoire of low-energy conformation changes that are known to occur in proteins. We first describe the basic elements of this repertoire, hinge and shear motions, and then show how the elements of the repertoire can be combined to produce domain movements. We emphasize that the elements used in particular proteins are determined mainly by the structure of the interfaces between the domains.
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Cites
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor
Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., & Steitz, T. A. (1992) · Science · doi:10.1126/science.1377403 · Cited by 1,914
Louie, G. V., Brownlie, P. D., Lambert, R., Cooper, J. B., Blundell, T. L., Wood, S. P., Warren, M. J., Woodcock, S. C., & Jordan, P. M. (1992) · Nature · doi:10.1038/359033a0 · Cited by 199
Cited by
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Halperin, I., Ma, B., Wolfson, H., & Nussinov, R. (2002) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.10115 · Cited by 1,294
Implications of protein flexibility for drug discovery
Teague, S. J. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1129 · Cited by 755
Multiple diverse ligands binding at a single protein site: A matter of pre‐existing populations
Ma, B., Shatsky, M., Wolfson, H. J., & Nussinov, R. (2002) · Protein Science · doi:10.1110/ps.21302 · Cited by 420
Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR
Tang, C., Schwieters, C. D., & Clore, G. M. (2007) · Nature · doi:10.1038/nature06232 · Cited by 416
Impact of protein conformational diversity on AlphaFold predictions
Saldaño, T., Escobedo, N., Marchetti, J., Zea, D. J., Mac Donagh, J., Velez Rueda, A. J., Gonik, E., García Melani, A., Novomisky Nechcoff, J., Salas, M. N., et al. (2022) · Bioinformatics · doi:10.1093/bioinformatics/btac202 · Cited by 196
Metadata
- Authors
- Gerstein, M., Lesk, A. M., & Chothia, C.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1994-06-07
- Volume
- 33
- Issue
- 22
- Pages
- 6739-6749
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2166905169
- Cited by
- 744
- References
- 2
- FWCI
- 12.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gerstein, M., Lesk, A. M., & Chothia, C. (1994). Structural Mechanisms for Domain Movements in Proteins. Biochemistry. https://doi.org/10.1021/bi00188a001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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