The DOI matches its Crossref record.
Induction of a New Metallothionein Isoform (MT-IV) Occurs during Differentiation of Stratified Squamous Epithelia
Abstract
A new member of the metallothionein (MT) gene family was discovered that lies about 20 kb 5' of the MT-III gene in both mouse and human. The MT-IV proteins are highly conserved in both species and have a glutamate insertion at position 5 relative to the classical MT-I and MT-II proteins. Murine MT-IV mRNA appears to be expressed exclusively in stratified squamous epithelia associated with oral epithelia, esophagus, upper stomach, tail, footpads, and neonatal skin. The MT derived from tongue epithelium contains both zinc and copper. Many of these epithelia develop parakeratosis during zinc deficiency in the rat. In situ hybridization reveals intense labeling of MT-IV mRNA in the differentiating spinous layer of cornified epithelia, whereas MT-I is expressed predominantly in the basal, proliferative layer; thus, there is a switch in MT isoform synthesis during differentiation of these epithelia. We suggest that MT-IV plays a special role in regulating zinc metabolism during the differentiation of stratified epithelia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Zinc homeostasis and neurodegenerative disorders
Szewczyk, B. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00033 · Cited by 288
Ogawa, Y., Kinoshita, M., Shimada, S., & Kawamura, T. (2018) · Nutrients · doi:10.3390/nu10020199 · Cited by 214
Metallothionein in the central nervous system: Roles in protection, regeneration and cognition
West, A. K., Hidalgo, J., Eddins, D., Levin, E. D., & Aschner, M. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2007.12.006 · Cited by 190
Zinc and Central Nervous System Disorders
Wang, B., Fang, T., & Chen, H. (2023) · Nutrients · doi:10.3390/nu15092140 · Cited by 93
Metallothionein: a Potential Link in the Regulation of Zinc in Nutritional Immunity
Rahman, M. T., & Karim, M. M. (2018) · Biological Trace Element Research · doi:10.1007/s12011-017-1061-8 · Cited by 77
Metadata
- Authors
- Quaife, C. J., Findley, S. D., Erickson, J. C., Froelick, G. J., Kelly, E. J., Zambrowicz, B. P., & Palmiter, R. D.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1994-06
- Volume
- 33
- Issue
- 23
- Pages
- 7250-7259
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2153685597
- Cited by
- 558
- References
- 0
- FWCI
- 21.70
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Induction of a New Metallothionein Isoform (MT-IV) Occurs during Differentiation of Stratified Squamous Epithelia. https://app.cochat.ai/papers/10.1021/bi00189a029
- The paper
- Quaife, C. J., Findley, S. D., Erickson, J. C., Froelick, G. J., Kelly, E. J., Zambrowicz, B. P., & Palmiter, R. D. (1994). Induction of a New Metallothionein Isoform (MT-IV) Occurs during Differentiation of Stratified Squamous Epithelia. Biochemistry. https://doi.org/10.1021/bi00189a029
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
