Zinc and Skin Disorders
Open accessAbstract
The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types of cells. Firstly, we review the physiological functions of Zn and Zn transporters in these cells. Several human disorders accompanied with skin manifestations are caused by mutations or dysregulation in Zn transporters; acrodermatitis enteropathica (Zrt-, Irt-like protein (ZIP)4 in the intestinal epithelium and possibly epidermal basal keratinocytes), the spondylocheiro dysplastic form of Ehlers-Danlos syndrome (ZIP13 in the dermal fibroblasts), transient neonatal Zn deficiency (Zn transporter (ZnT)2 in the secretory vesicles of mammary glands), and epidermodysplasia verruciformis (ZnT1 in the epidermal keratinocytes). Additionally, acquired Zn deficiency is deeply involved in the development of some diseases related to nutritional deficiencies (acquired acrodermatitis enteropathica, necrolytic migratory erythema, pellagra, and biotin deficiency), alopecia, and delayed wound healing. Therefore, it is important to associate the existence of mutations or dysregulation in Zn transporters and Zn deficiency with skin manifestations.
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Minerals such as copper, zinc, and selenium play important roles in skin health.
“In addition, minerals such as copper, zinc, and selenium also play important roles in skin health [19,153,154].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [153]
The skin is the third most zinc-abundant tissue in the body, with greater amounts in the epidermis than in the dermis.
“The skin is the third most Zn-abundant tissue in the body, with greater amounts in the epidermis than in the dermis [99,102].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [99]
Zinc preparations in the form of pastes or ointments cleanse the skin of excess sebum, restore its natural pH, and have astringent, anti-inflammatory and anti-acne effects.
“Zinc preparations in the form of pastes or ointments cleanse the skin of excess sebum, restore its natural pH, and have astringent, anti-inflammatory and anti-acne effects.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [99]
Zinc affects the immune function of the skin, modulating macrophage and neutrophil functions, phagocytic activity and various inflammatory cytokines.
“Zinc also affects the immune function of the skin, modulating macrophage and neutrophil functions, phagocytic activity and various inflammatory cytokines [98,99].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [99]
The oral and/or topical administration of zinc has long been used for its effect on skin regeneration and healing.
“The oral and/or topical administration of Zn has long been used for its effect on skin regeneration and healing [99,109].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [99]
Zinc is used to treat numerous dermatological conditions, such as infections, inflammatory dermatoses and pigmentary disorders.
“Zinc is used to treat numerous dermatological conditions, such as infections (e.g., warts), inflammatory dermatoses (acne vulgaris, rosacea, atopic dermatitis and alopecia areata) and pigmentary disorders (melasma) [97,98,99,107,110].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [99]
Zinc oxide, due to its ability to reflect and disperse UV rays, is used as a physical filter in sunscreens.
“Zinc oxide, due to its ability to reflect and disperse UV rays, is used as a physical filter in sunscreens [97,98,99,107,110].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [99]
Zinc content in the skin ranks third among all tissues and is essential for proliferation and differentiation of skin epidermal keratinocytes.
“Zinc content in the skin ranks third among all tissues and is an essential element for the proliferation and differentiation of skin epidermal keratinocytes [60,61].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [61]
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- Authors
- Ogawa, Y., Kinoshita, M., Shimada, S., & Kawamura, T.
- Affiliations
- University of Yamanashi (JP)
- Corresponding author
- Ogawa, Youichi
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2018-02-11
- Volume
- 10
- Issue
- 2
- Pages
- 199
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5852775
- OpenAlex
- W2790343435
- Cited by
- 214
- References
- 176
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 33 · 2023: 29 · 2022: 31 · 2021: 23 · 2020: 31 · 2019: 25 · 2018: 3
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (18K16022)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Keywords
- zinc, zinc transporters, skin diseases, acrodermatitis enteropathica, ZIP4, Ehlers-Danlos syndrome, ZIP13, ZnT2, ZnT1, epidermodysplasia verruciformis, zinc deficiency, necrolytic migratory erythema, pellagra, biotin deficiency, hair loss, delayed wound healing, keratinocytes, dermal fibroblasts, intestinal epithelium
- MeSH terms
- Carrier Proteins, Deficiency Diseases, Fibroblasts, Humans, Mutation, Skin, Skin Diseases, Zinc, Keratinocytes, Cation Transport Proteins
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