The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity
Abstract
High-level glycopeptide resistance in Enterococcus faecium BM4147 is mediated by a 38-kDa protein VanA, whose amino acid sequence is related to Gram-negative D-alanine:D-alanine (D-Ala-D-Ala) ligases [Dutka-Malen, S., Molinas, C., Arthur, M., & Courvalin, P. (1990) Mol. Gen. Genet. 224, 364-372]. We report purification of VanA and demonstrate that it has D-Ala-D-Ala ligase activity but has substantially modified substrate specificity, compared with Gram-negative D-Ala-D-Ala ligases. VanA preferentially condenses D-Ala with D-Met or D-Phe, raising the possibility that its cellular role is to synthesize a modified cell-wall component, which is subsequently not recognized by vancomycin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Structure, biochemistry and mechanism of action of glycopeptide antibiotics
Reynolds, P. E. (1989) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01967563 · Cited by 699
Cited by
The crisis in antibiotic resistance
Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834
Vancomycin-Resistant Enterococci
Cetinkaya, Y., Falk, P., & Mayhall, C. G. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.4.686 · Cited by 1,163
Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications
Hu, F., Xu, S., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201801350 · Cited by 859
Genetics and mechanisms of glycopeptide resistance in enterococci
Arthur, M., & Courvalin, P. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.8.1563 · Cited by 694
Self-citationEmergence of Enterococcus as a Significant Pathogen
Moellering, R. C. (1992) · Clinical Infectious Diseases · doi:10.1093/clinids/14.6.1173 · Cited by 578
Metadata
- Authors
- Bugg, T. D. H., Dutka-Malen, S., Arthur, M., Courvalin, P., & Walsh, C. T.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1991-02-01
- Volume
- 30
- Issue
- 8
- Pages
- 2017-2021
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2074092417
- Cited by
- 223
- References
- 1
- FWCI
- 11.37
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity. https://app.cochat.ai/papers/10.1021/bi00222a002
- The paper
- Bugg, T. D. H., Dutka-Malen, S., Arthur, M., Courvalin, P., & Walsh, C. T. (1991). Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity. Biochemistry. https://doi.org/10.1021/bi00222a002
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
