The crisis in antibiotic resistance

Neu, Harold C.

doi:10.1126/science.257.5073.1064

Cited by 2,834Antibiotic Resistance in BacteriaAntibiotic Use and ResistanceAntimicrobial Resistance in Staphylococcus

The crisis in antibiotic resistance

Neu, Harold C.·1992·Science

DOI 10.1126/science.257.5073.1064

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Abstract

The synthesis of large numbers of antibiotics over the past three decades has caused complacency about the threat of bacterial resistance. Bacteria have become resistant to antimicrobial agents as a result of chromosomal changes or the exchange of the exchange of genetic material via plasmids and transposons. Streptococcus pneumoniae, Streptococcus pyogenes, and staphylococci, organisms that cause respiratory and cutaneous infections, and members of the Enterobacteriaceae and Pseudomonas families, organisms that cause diarrhea, urinary infection, and sepsis, are now resistant to virtually all of the older antibiotics. The extensive use of antibiotics in the community and hospitals has fueled this crisis. Mechanisms such as antibiotic control programs, better hygiene, and synthesis of agents with improved antimicrobial activity need to be adopted in order to limit bacterial resistance.

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Ventilator-associated Pneumonia
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Authors: Neu, H. C.
Affiliations: Columbia University (US)
Corresponding author: Neu, Harold C.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1992-08-21
Volume: 257
Issue: 5073
Pages: 1064-1073
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.257.5073.1064
OpenAlex: W1980595924
Cited by: 2,834
References: 109
Citations by year: 2026: 23 · 2025: 48 · 2024: 57 · 2023: 71 · 2022: 91 · 2021: 93 · 2020: 123 · 2019: 100 · 2018: 122 · 2017: 123 · 2016: 105 · 2015: 87 · 2014: 95 · 2013: 109 · 2012: 99
FWCI: 46.70
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords: antibiotic resistance, bacterial resistance, plasmids, transposable elements, horizontal gene transfer, Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus, Enterobacteriaceae, Pseudomonas, antibiotic overuse, hygiene, novel antimicrobial agents
MeSH terms: Anti-Bacterial Agents, Bacterial Infections, Cross Infection, Drug Resistance, Microbial, Enterobacteriaceae, Haemophilus influenzae, Humans, Staphylococcus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus

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