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Structure and metabolism of mammalian liver glycogen monitored by carbon-13 nuclear magnetic resonance
Abstract
Natural-abundance 13C NMR signals from glycogen are observable in situ within the perfused livers of rats. The nuclear magnetic relaxation properties (T1, T2, eta + 1) of glycogen were measured for glycogen in situ and in vitro and were found to be identical. All of the carbon nuclei in glycogen contribute to the high-resolution NMR spectrum, in spite of glycogen's very large molecular weight. The metabolism of glycogen in situ in the perfused rat liver was followed by 13C NMR. Stimulation of the fed rat liver by physiological glucagon levels led to rapid glycogenolysis. Perfusion of the liver with [1-13C]glucose led to net glycolysis, with concomitant scrambling of the label from C1 to C6 due to triosephosphate isomerase activity.
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Cited by
Quantitation of Hepatic Glycogenolysis And Gluconeogenesis in Fasting Humans With 13 C NMR
Rothman, D. L., Magnusson, I., Katz, L. D., Shulman, R. G., & Shulman, G. I. (1991) · Science · doi:10.1126/science.1948033 · Cited by 546
Self-citationStructural analysis of glucans.
Synytsya, A., & Novák, M. (2014) · PubMed · doi:10.3978/j.issn.2305-5839.2014.02.07 · Cited by 332
Chance, E. M., Seeholzer, S. H., Kobayashi, K., & Williamson, J. R. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43987-1 · Cited by 273
Casey, A., Mann, R., Banister, K., Fox, J., Morris, P. G., Macdonald, I. A., & Greenhaff, P. L. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.1.e65 · Cited by 140
Metadata
- Authors
- Sillerud, L. O., & Shulman, R. G.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1983-03-01
- Volume
- 22
- Issue
- 5
- Pages
- 1087-1094
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2040396962
- Cited by
- 170
- References
- 0
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sillerud, L. O., & Shulman, R. G. (1983). Structure and metabolism of mammalian liver glycogen monitored by carbon-13 nuclear magnetic resonance. Biochemistry. https://doi.org/10.1021/bi00274a015
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